Lifeboat Foundation

Researchers at Princeton University have revealed the inner workings of a gene repression mechanism in fruit fly embryos, adding insight to the study of human diseases.

Led by graduate student Shannon Keenan, the team used light to activate chemical signals in developing fruit flies and traced the effects on a protein called Capicua, or Cic. Located in a cell’s nucleus, Cic binds to DNA and performs the specialized task of silencing genes. The study, published in Developmental Cell and made available online March 5, reveals the dynamics of gene repression by this protein.

In a complex piece of music, the silences running through the melody contribute as much to the score’s effect as the sounded notes. The biological processes that control development rely on highly sophisticated temporal patterns of gene activation and repression to create life’s beautiful symphonies. When a pattern is disrupted, it’s like a wrong note in the music. In this case, Cic is a repressor protein that silences certain parts of the genome, allowing other genes to express in harmony with one another. Understanding how repressors like Cic work allows researchers to better conduct the orchestra.

The origins are still too unknown. This is entirely new life a more parasitic lifeform. Bit still new lifeforms entirely. My experiencers tell me of alien origin though the rate of spread also the complexity. No human could make this no even government can make this. We can mimic life not create something new. Sure new things can be added but the signature tells me it is definitely of alien origin. Not even nature can create something this quick nor even governments. Sure there may be like similar things but why does it spread so fast in near systematic precision. Which leads to essentially of exterrestial origin. This is essentially new life we are dealing with.

Nat Rev Microbiol. 2019 Mar;17:181–192. doi: 10.1038/s41579-018‑0118-9.

Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in bats, and genetically diverse coronaviruses that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide. In this Review, we summarize the current knowledge on the origin and evolution of these two pathogenic coronaviruses and discuss their receptor usage; we also highlight the diversity and potential of spillover of bat-borne coronaviruses, as evidenced by the recent spillover of swine acute diarrhoea syndrome coronavirus (SADS-CoV) to pigs.

Whether man made or alien made or whatever a chimeric vaccine could essentially cure the illness.

Chimeric vaccines consisting of a series of immunodominant epitopes have been explored in the development of vaccines against malaria ( Hanson and Edelman, 2004 ; Caro-Aguilar et al., 2005 ), group A streptococci ( Dale, 1999 ; Hu et al., 2002 ; Kotloff et al., 2004 ; Kotloff and Dale, 2004 ; Dale et al., 2005 ; McNeil et al., 2005 ), and several viruses ( Wang et al., 1999d ; Bouche et al., 2005 ; Fan et al., 2005 ; Apt et al., 2006 ). Data suggest that a broadly protective OspC vaccine will require the inclusion of epitopes from approximately 28 OspC types ( Earnhart and Marconi, 2007c ). Such a construct is predicted to provide protection against all major Lyme disease spirochete species associated with human disease, and to be effective in both Europe and North America. Possible cross-protection elicited by some epitopes may reduce the total number of epitopes required to achieve this goal.

A prototype tetravalent chimeric recombinant OspC-based vaccine has been produced that incorporates epitope-containing regions from types A, B, K, and D. This “ABKD” vaccine elicited antibodies in mice that bind OspC as presented on the surface of intact and viable spirochetes and mediate bactericidal activity by a complement-dependent mechanism ( Buckles et al., 2006 ; Earnhart et al., 2007 ). It is noteworthy that a decrease in epitope-specific titer was observed for epitopes progressing from the N- to the C-terminus of the chimeric protein. The antibody titer to the type D epitope was 1.7 logs lower than that observed for the N-terminally located type A epitope ( Earnhart et al., 2007 ). This effect did not appear to be due to C-terminal degradation of the construct since the addition of C-terminal tags that have been reported to stabilize recombinant proteins did not improve antibody titer ( Earnhart and Marconi, 2007a ).

Quantum computing isn’t yet far enough along that it could have helped curb the spread of this coronavirus outbreak. But this emerging field of computing will almost certainly help scientists and researchers confront future crises.

“Can we compress the rate at which we discover, for example, a treatment or an approach to this?” asks Dario Gil, the director of IBM Research. “The goal is to do everything that we are doing today in terms of discovery of materials, chemistry, things like that, (in) factors of 10 times better, 100 times better,”

And that, he says, “could be game-changing.”

A population of stem cells with the ability to generate new bone has been newly discovered by a group of researchers at the UConn School of Dental Medicine.

In the journal Stem Cells, lead investigator Dr. Ivo Kalajzic, professor of reconstructive sciences, postdoctoral fellows Dr. Sierra Root and Dr. Natalie Wee, and collaborators at Harvard, Maine Medical Research Center, and the University of Auckland present a new population of cells that reside along the vascular channels that stretch across the bone and connect the inner and outer parts of the bone.

“This is a new discovery of perivascular cells residing within the bone itself that can generate new bone forming cells,” said Kalajzic. “These cells likely regulate bone formation or participate in bone mass maintenance and repair.”

Essentially the microchip that heals article turns the normal process of healing into an accelerated way but eventually crispr could be used to make super fast healing and regeneration.

Normal wound healing is a dynamic and complex multiple phase process involving coordinated interactions between growth factors, cytokines, chemokines, and various cells. Any failure in these phases may lead wounds to become chronic and have abnormal scar formation. Chronic wounds affect patients’ quality of life, since they require repetitive treatments and incur considerable medical costs. Thus, much effort has been focused on developing novel therapeutic approaches for wound treatment. Stem-cell-based therapeutic strategies have been proposed to treat these wounds. They have shown considerable potential for improving the rate and quality of wound healing and regenerating the skin. However, there are many challenges for using stem cells in skin regeneration. In this review, we present some sets of the data published on using embryonic stem cells, induced pluripotent stem cells, and adult stem cells in healing wounds. Additionally, we will discuss the different angles whereby these cells can contribute to their unique features and show the current drawbacks.

Tony Stark’s bleeding edge armor was first featured in Avengers: Infinity War, and while it had some cool moments, there’s actually a lot more to it.

Italy’s prime minister has said at least 16 million people are in mandatory quarantine in Lombardy region and also in 14 provinces.

The lock-down will last until early April.

The dramatic escalation in the country’s efforts to contain the new coronavirus will close gyms, pools, museums and ski resorts.

Wuhan Coronavirus Pandemic Washington State.

More deaths and it looks like they’re going to look at previous deaths at the retirement home that is the epicenter to see if some of those previous deaths were caused by Wuhan Coronavirus.

“Killian went on to say that since February 19, Life Care Center reported 26 deaths. Since that date, 11 additional patients died at the facility. They generally have three to seven deaths a month, Killian said. Life Care Center is still waiting back for reports on post-mortem testing and whether 11 of those patients tested positive for coronavirus.”

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