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Category: biotech/medical – Page 29

Scientists Have Discovered a Protein That Reverses Brain Aging in The Lab

Our brains age along with the rest of our bodies, and as they do, they produce fewer new brain cells. Now, researchers have found a key mechanism through which the typical age-related decline in neuron production might be slowed.

In later life, the neural stem cells (NSCs) that turn into fully fledged neurons become more dormant – almost as if they’re going into retirement after a long lifetime of service. As that happens, cognitive decline creeps in.

A major reason why NSC activity fades with age is the wear and tear on telomeres, the protective caps on the ends of DNA. Telomeres fray a little more each time a cell divides, and over time, this impairs cells’ ability to grow and divide, leading to increasing cell death.

Anti-Aging Breakthrough: Regenerate Your Liver

NewLimit just announced something that could be a major step toward real anti-aging medicine:
their first therapy is designed to regenerate the liver potentially making it 10–20 years younger.
Human trials are still ahead, but they’re already working on similar approaches for the immune system and vascular system.
Cartilage. Teeth. Liver.
Regeneration is moving from science fiction to clinical reality.
And it raises a bigger question:
medicine today often requires lifelong dosing like GLP-1 weight loss drugs (Ozempic, Wegovy).
What if the future is different?
What if one shot could actually repair the system instead of managing it forever?

Natural history of craniocervical alignment in Chiari patients and the impact of posterior fossa decompression

Chiari malformation (CM) involves a broad disease spectrum, where rare complex CM cases can be associated with craniocervical junction (CVJ) instability and require occipitocervical fusion. However, the natural progression of CVJ alignment in the general CM type I and 1.5 populations treated with posterior fossa decompression (PFD) remains insufficiently characterized. The authors aimed to compare CVJ alignment changes in patients who underwent PFD versus patients with CM who did not undergo surgery.

The authors conducted a retrospective cohort study at their institution of all patients diagnosed with CM I and 1.5 from 2000 to early 2023. Demographic, clinical, and surgical data were collected, along with preoperative and postoperative MRI measurements, including tonsillar herniation, brainstem descent, clivoaxial angle (CXA), and condylar-C2 sagittal vertical alignment (C-C2SVA).

A total of 241 patients were included, with 201 undergoing PFD and 40 managed conservatively (controls). No significant differences were observed between groups in age at diagnosis, sex, or genetic diagnoses. In the PFD group, 55% underwent duraplasty and 45% underwent bone-only decompression. Baseline craniocervical alignment measurements showed a lower CXA in the PFD group (144.4° ± 13.4°) compared to controls (148.5° ± 14.2°) (p = 0.04) but no difference in C-C2SVA. Changes over time showed a small but significant decrease in CXA at < 1 year after surgery in the PFD group (−2.7°) compared to controls (−2.0°) (p = 0.008), but no differences were noted at 1–2 years. No differences in C-C2SVA were observed over time in either group.

This Scientist Brewed and Drank His Own ‘Vaccine Beer’ to Combat a Dangerous Virus. It Seems to Have Worked

Blood tests revealed that the beverage elicited an immune response, according to preliminary research. But far more safety and efficacy testing would be needed before this vaccine could become available

The ‘Miracle Mineral Solution’—amazing cure or toxic illusion?

Miracle Mineral Solution, also known as MMS, has been marketed for years as a purported miracle cure for various conditions, including cancer, autism, and COVID-19. MMS is the marketing name for sodium chlorite (NaClO₂), a powerful disinfectant used, among other things, for water treatment. When sodium chlorite is acidified, chlorine dioxide (ClO₂) is formed. Its consumption can be hazardous to health.

A team of scientists from Wroclaw Medical University decided to investigate this.

In a study published in Scientific Reports, they analyzed the effects of acidified sodium chlorite (ASC), from which ClO₂ is produced.

How Epigenetic Reprogramming Makes Cells Act Young Again

Aging doesn’t rewrite your DNA, it scrambles how your cells read it.

This clip explains epigenetic drift and how Life Biosciences’ therapy, ER100, uses Yamanaka factors to restore youthful epigenetic patterns in aged cells. By resetting the chemical marks that control gene expression, cells can behave as if they’re young again without changing the underlying DNA.

It’s the same biological process that happens early in embryonic development, applied in a controlled way to adult cells.

Abstract: In a cohort of over 1,000 patients with BreastCancer

Emilio Hirsch & team identify SH3BP5L as the most highly expressed guanine nucleotide exchange factor (GEF) for RAB11A, and its inhibition lowers lung metastasis and cell spreading in triple negative breast cancer models (TNBC):

The figure shows immunohistochemical assessment of SH3BP5L expression in tissue from patients with breast cancer.

@unito.it @fondazioneumbertoveronesi

1Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center “G. Tarone,” University of Torino, Torino, Italy.

2IEO, European Institute of Oncology IRCCS, Milan, Italy.

3Department of Oncology and Hemato-Oncology, University of Milano, Milano, Italy.

Continue reading “Abstract: In a cohort of over 1,000 patients with BreastCancer” | >

Antibodies block bacteria that cause tuberculosis, study shows

A study led by UT Southwestern Medical Center researchers has found that certain antibodies inhibit Mycobacterium tuberculosis, the cause of tuberculosis (TB), the infectious disease that claims the most lives worldwide. Published in Cell Reports, the study identified characteristics of these antibodies and revealed insights that may lead to clinical tools that help prevent TB and other diseases.

“This data changes how we think about using the immune system against tuberculosis by showing how some antibodies activate immune cells in patients to block Mycobacterium tuberculosis (Mtb),” said the study’s senior author, Lenette Lu, M.D., Ph.D., Assistant Professor of Internal Medicine and Immunology and a member of the Division of Infectious Diseases and Geographic Medicine at UT Southwestern.

Despite widespread use of Bacillus Calmette-Guérin (BCG), the only licensed TB vaccine, the Centers for Disease Control and Prevention (CDC) estimates that 10.8 million people became ill with TB in 2023 and 1.25 million died.

“The Bioelectric Interface to the Collective Intelligence of Morphogenesis” by Michael Levin

This is a ~57 minute talk titled “The Bioelectric Interface to the Collective Intelligence of Morphogenesis: development, regeneration, cancer, and beyond” which I gave at a UCSF seminar for an audience of graduate students and post-docs in Biophysics, Bioinformatics, and Chemical Biology. I covered the role of bioelectricity as cognitive glue underlying high-level adaptive plasticity in living tissue, recent progress in exploiting that interface, and new developments in research platforms for this field.

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