Lifeboat Foundation

Brain-machine interfaces (BMIs) have emerged as a promising solution for restoring communication and control to individuals with severe motor impairments. Traditionally, these systems have been bulky, power-intensive, and limited in their practical applications. Researchers at EPFL have developed the first high-performance, Miniaturized Brain-Machine Interface (MiBMI), offering an extremely small, low-power, highly accurate, and versatile solution.

Published in the latest issue of the IEEE Journal of Solid-State Circuits (“MiBMI: A 192/512-Channel 2.46mm 2 Miniaturized Brain-Machine Interface Chipset Enabling 31-Class Brain-to-Text Conversion Through Distinctive Neural Codes”) and presented at the International Solid-State Circuits Conference, the MiBMI not only enhances the efficiency and scalability of brain-machine interfaces but also paves the way for practical, fully implantable devices. This technology holds the potential to significantly improve the quality of life for patients with conditions such as amyotrophic lateral sclerosis (ALS) and spinal cord injuries.

An image of the chip. (Image: EPFL)

Sensors that can be easily and safely introduced in the brain could have important medical applications and could also contribute to the development of brain-interfacing devices. While significant progress has been made toward the development of these sensors, most existing devices can only be deployed via invasive surgical procedures that can have numerous complications.

Researchers at Seoul National University and other institutes in South Korea recently created a new biodegradable and self-deployable tent electrode that could be far easier to insert onto the surface of the human brain. Their proposed electrode design, outlined in Nature Electronics, could naturally degrade inside the human body without leaving any residues, which means that once it is inserted in the body it does not need to be surgically removed.

“Our recent paper was born out of a growing awareness of the clinical challenges linked to the implantation of electrodes via invasive brain surgery,” Seung-Kyun Kang, corresponding author of the paper, told Medical Xpress.

Noninvasive braincomputer interfaces could vastly improve brain computer control.

Over the past two decades, the international biomedical research community has demonstrated increasingly sophisticated ways to allow a person’s brain to communicate with a device, allowing breakthroughs aimed at improving quality of life, such as access to computers and the internet, and more recently control of a prosthetic limb. DARPA has been at the forefront of this research.

The state of the art in brain-system communications has employed invasive techniques that allow precise, high-quality connections to specific neurons or groups of neurons. These techniques have helped patients with brain injury and other illnesses. However, these techniques are not appropriate for able-bodied people. DARPA now seeks to achieve high levels of brain-system communications without surgery, in its new program, Next-Generation Nonsurgical Neurotechnology (N³).

Continue reading “Nonsurgical Neural Interfaces Could Significantly Expand Use of Neurotechnology” »

A newly discovered code within DNA—coined “spatial grammar”—holds a key to understanding how gene activity is encoded in the human genome.

This breakthrough finding, identified by researchers at Washington State University and the University of California, San Diego and published in Nature, revealed a long-postulated hidden spatial grammar embedded in DNA. The research could reshape scientists’ understanding of gene regulation and how genetic variations may influence gene expression in development or disease.

Transcription factors, the proteins that control which genes in one’s genome are turned on or off, play a crucial role in this code. Long thought of as either activators or repressors of gene activity, this research shows the function of transcription factors is far more complex.

Dr. Vopson proposes that information has mass and is the fifth state of matter, expanding our current understanding of the universe’s basic building blocks.

Physicist Dr. Melvin Vopson from the University of Portsmouth has proposed an experiment to prove that information is the fifth state of matter, alongside solid, liquid, gas, and plasma. His theory suggests that information possesses mass and is a fundamental component of the universe, similar to DNA in living organisms. The experiment involves using particle-antiparticle collisions to detect and measure this information. If proven correct, this could radically change our understanding of physics, suggesting that information might even be the elusive dark matter that makes up nearly a third of the universe.

After reading the article, a Reddit user gained more than 1.7k upvotes with this comment: “Here’s explanation: When you collide an electron and a positron (an anti-electron) they are completely destroyed, releasing their mass equivalent energy as photons. The information equivalence theory predicts that you aren’t just destroying the mass but also internal information the particle has. If this is true, the annihilation would also release photons equal to the information-energy equivalence.” This article will amaze you by showing how information might be the key to unlocking the mysteries of the universe. Don’t forget to discuss this fascinating theory in the comment section below!

Here, the authors present a data storage and computation engine comprised of DNA adsorbed to soft dendricolloids, demonstrating end-to-end capabilities from archival storage to non-destructive file access for reading, erasing, rewriting and computing.

“DNA, RNA and proteins are the key players to regulate all processes in the cells of our body,” Leiden Professor John van Noort explains. “To understand the (mis-)functioning of these molecules, it is essential to uncover how their 3D structure depends on their sequence and for this it is necessary to measure them one molecule at a time. However, single-molecule measurements are laborious and slow, and the number of possible sequence variations is massive.”

Now the team of scientists developed an innovative tool, called SPARXS (Single-molecule Parallel Analysis for Rapid eXploration of Sequence space), that allows for studying millions of DNA molecules simultaneously.

Continue reading “Revealing DNA behavior in record time (w/video)” »

CRISPR-Cas systems, defense systems in bacteria, have become a plentiful source of technologies for molecular diagnostics. Researchers at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg have expanded this extensive toolbox. Their novel method, called PUMA, enables the detection of RNA with Cas12 nucleases, which naturally target DNA. PUMA promises a wide range of applications and high accuracy.

The team published its results in the journal Nature Communications (“TracrRNA reprogramming enables direct PAM-independent detection of RNA with diverse DNA-targeting Cas12 nucleases”).

Bacteria have developed special defense mechanisms to protect themselves against viruses, which by no means infect only humans. As part of these so-called CRISPR-Cas systems, a CRISPR ribonucleic acid (crRNA), which serves as a “guide RNA,” recognizes regions of a foreign genome, such as viral DNA. The CRISPR-associated (Cas) nuclease, directed by a crRNA, then renders it harmless by cutting it like a pair of scissors.

Researchers worldwide can now create highly realistic brain cortical organoids — essentially miniature artificial brains with functioning neural networks — thanks to a proprietary protocol released this month by researchers at the University of California San Diego.

The new technique, published in Nature Protocols (“Generation of ‘semi-guided’ cortical organoids with complex neural oscillations”), paves the way for scientists to perform more advanced research regarding autism, schizophrenia and other neurological disorders in which the brain’s structure is usually typical, but electrical activity is altered. That’s according to Alysson Muotri, Ph.D., corresponding author and director of the UC San Diego Sanford Stem Cell Institute (SSCI) Integrated Space Stem Cell Orbital Research Center. The SSCI is directed by Dr. Catriona Jamieson, a leading physician-scientist in cancer stem cell biology whose research explores the fundamental question of how space alters cancer progression.

The newly detailed method allows for the creation of tiny replicas of the human brain so realistic that they rival “the complexity of the fetal brain’s neural network,” according to Muotri, who is also a professor in the UC San Diego School of Medicine’s Departments of Pediatrics and Cellular and Molecular Medicine. His brain replicas have already traveled to the International Space Station (ISS), where their activity was studied under conditions of microgravity.