Lifeboat Foundation

Proteins can communicate through DNA, conducting a long-distance dialogue that serves as a kind of genetic “switch,” according to Weizmann Institute of Science researchers. They found that the binding of proteins to one site of a DNA molecule can physically affect another binding site at a distant location, and that this “peer effect” activates certain genes. This effect had previously been observed in artificial systems, but the Weizmann study is the first to show it takes place in the DNA of living organisms.

A team headed by Dr. Hagen Hofmann of the Chemical and Structural Biology Department made this discovery while studying a peculiar phenomenon in the soil bacteria Bacillus subtilis. A small minority of these bacteria demonstrate a unique skill: an ability to enrich their genomes by taking up bacterial gene segments scattered in the soil around them. This ability depends on a protein called ComK, a transcription factor, which binds to the DNA to activate the genes that make the scavenging possible. However, it was unknown how exactly this activation works.

Devices in the submillimetre range – so-called “nano-supercapacitors” – allow the shrinkage of electronic components to tiny dimensions. However, they are difficult to produce and do not usually incorporate biocompatible materials. Corrosive electrolytes, for example, can quickly discharge themselves in the event of defects and contamination.

So-called “biosupercapacitors” (BSCs) offer a solution. These have two outstanding properties: full biocompatibility, which means they can be used in body fluids such as blood, and compensation for self-discharge behaviours through bio-electrochemical reactions. In other words, they can actually benefit from the body’s own reactions. This is because, in addition to typical charge storage reactions of a supercapacitor, redox enzymatic reactions and living cells naturally present in the blood can increase the performance of a device by 40%.

Shrinking these devices down to submillimetre sizes, while maintaining full biocompatibility, has been enormously challenging. Now, scientists have created a prototype that combines both essential properties.

Studying Novel Plasma Fractions For Age-Related Diseases And Systemic Rejuvenation — Dr. Harold Katcher Ph.D., Chief Scientific Officer, Yuvan Research Inc.

Dr. Harold Katcher is the Chief Scientific Officer at Yuvan Research Inc., a biotech company exploring the development of novel, young plasma fraction rejuvenation treatments in mammals.

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Secretome Derived Regenerative Therapeutics — Dr. Hanadie Yousef Ph.D., Co-Founder & CEO, Juvena Therapeutics

Dr. Hanadie Yousef, Ph.D. is a Scientist, Co-Founder and CEO of Juvena Therapeutics (https://www.juvenatherapeutics.com/), a regenerative medicine company developing protein therapeutics to promote tissue regeneration and increase healthspan, to prevent, reverse, and cure degenerative diseases.

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Water is the most abundant yet least understood liquid in nature. It exhibits many strange behaviors that scientists still struggle to explain. While most liquids get denser as they get colder, water is most dense at 39 degrees Fahrenheit, just above its freezing point. This is why ice floats to the top of a drinking glass and lakes freeze from the surface down, allowing marine life to survive cold winters. Water also has an unusually high surface tension, allowing insects to walk on its surface, and a large capacity to store heat, keeping ocean temperatures stable.

Now, a team that includes researchers from the Department of Energy’s SLAC National Accelerator Laboratory, Stanford University and Stockholm University in Sweden have made the first direct observation of how hydrogen atoms in water molecules tug and push neighboring water molecules when they are excited with laser light. Their results, published in Nature today, reveal effects that could underpin key aspects of the microscopic origin of water’s strange properties and could lead to a better understanding of how water helps proteins function in living organisms.

“Although this so-called nuclear quantum effect has been hypothesized to be at the heart of many of water’s strange properties, this experiment marks the first time it was ever observed directly,” said study collaborator Anders Nilsson, a professor of chemical physics at Stockholm University. “The question is if this quantum effect could be the missing link in theoretical models describing the anomalous properties of water.”

Pico technology is hypothetical future level of technology which will revolutionized the scientist world. This technology is combination of pico and meter with scale of trillionths of a meter (10⁻¹²). This atomic and subatomic range particles reveals extraordinary properties and pave the way for tremendous applications [1].

The way lengths and angles attach together is the main determine of the materials properties. Alterable or reversible bonds distortions at pico-meter scale which changes the electronic conformation causes multiple properties for materials.

On the other hand, pico-scale particles changes the material properties by converting energy state of electrons within an atom. Physical and chemical properties of systems such as melting point, fluorescence, electrical conductivity, magnetic permeability, and chemical reactivity changes basically at pico-scale due to quantum effects of materials [2]. Moreover, surface energy of atoms increases by alternation of electron distribution and therefore, enhances protein and molecules adsorption on to materials. This privileges will resulting in tracing proteins, DNA and molecules and labeling them for various purpose.

Lipids are abundant in the brain, where they are found not just in the cell membranes of neurons, whose properties they modulate, but also in the so-called myelin sheaths insulating axons — the brain’s ‘wiring.’ The brain is therefore a surprisingly ‘fat’ organ — in fact, it is nearly 60% fat, the study’s first author, Anna Tkachev from Skoltech, said.

Summary: Prozac reduced polyunsaturated fatty acid lipid concentrations in the brains of juvenile macaque monkeys.

Source: Skoltech

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#Biology #biochemistry #Biochemist #biotech #bio

This video explains introduction to biochemistry.

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Circa 2014

Scientists in a lab used a powerful laser to re-create what might have been the original spark of life on Earth.

The researchers zapped clay and a chemical soup with the laser to simulate the energy of a speeding asteroid smashing into the planet. They ended up creating what can be considered crucial pieces of the building blocks of life.

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