Lifeboat Foundation

With the new method, scientists can explore many cancer mutations whose roles are unknown, helping them develop new drugs that target those mutations.

MIT

MIT is an acronym for the Massachusetts Institute of Technology. It is a prestigious private research university in Cambridge, Massachusetts that was founded in 1861. It is organized into five Schools: architecture and planning; engineering; humanities, arts, and social sciences; management; and science. MIT’s impact includes many scientific breakthroughs and technological advances. Their stated goal is to make a better world through education, research, and innovation.

When most people think of crystals, they picture suncatchers that act as rainbow prisms or the semi-transparent stones that some believe hold healing powers. However, to scientists and engineers, crystals are a form of materials in which their constituents—atoms, molecules, or nanoparticles—are arranged regularly in space. In other words, crystals are defined by the regular arrangement of their constituents. Common examples are diamonds, table salt, or sugar cubes.

However, in research just published in Soft Matter, a team led by Rensselaer Polytechnic Institute’s Sangwoo Lee, associate professor in the Department of Chemical and Biological Engineering, discovered that crystal structures are not necessarily always regularly arranged. The discovery advances the field of materials science and has unrealized implications for the materials used for semiconductors, solar panels, and electric vehicle technologies.

One of the most common and important classes of crystal structures is the close-packed structures of regular spheres constructed by stacking layers of spheres in a honeycomb arrangement. There are many ways to stack the layers to construct close-packed structures, and how nature selects specific stacking is an important question in materials and physics research. In the close-packing construction, there is a very unusual structure with irregularly spaced constituents known as the random stacking of two-dimensional hexagonal layers (RHCP). This structure was first observed from cobalt metal in 1942, but it has been regarded as a transitional and energetically unpreferred state.

A University of Minnesota Twin Cities-led team has developed a first-of-its-kind, breakthrough method that makes it easier to create high-quality metal oxide thin films out of “stubborn” metals that have historically been difficult to synthesize in an atomically precise manner. This research paves the way for scientists to develop better materials for various next-generation applications including quantum computing, microelectronics, sensors, and energy catalysis.

The researchers’ paper is published in Nature Nanotechnology.

“This is truly remarkable discovery, as it unveils an unparalleled and simple way for navigating material synthesis at the atomic scale by harnessing the power of epitaxial strain,” said Bharat Jalan, senior author on the paper and a professor and Shell Chair in the University of Minnesota Department of Chemical Engineering and Materials Science.

Biosensors are artificial molecular complexes designed to detect the presence of target chemicals or even biomolecules. Consequently, biosensors have become important in diagnostics and synthetic cell biology. However, typical methods for engineering biosensors focus on optimizing the interactions between static binding surfaces, and current biosensor designs can only recognize structurally well-defined molecules, which can be too rigid for “real-life” biology.

“We developed a novel computational approach for designing protein-peptide ligand binding and applied it to engineer cell-surface chemotactic receptors that reprogrammed cell migration,” says EPFL professor Patrick Barth. “We think that our work could broadly impact the design of protein binding and cell engineering applications.”

The new biosensors developed by Barth’s group can sense flexible compounds and trigger complex cellular responses, which open up new possibilities for biosensor applications. The researchers created a computational framework, which is a computer-based system, for designing protein complexes that can change their shape and function dynamically—as opposed to the conventional static approaches. The framework can look at previously unexplored protein sequences to come up with new ways for the protein’s groups to be activated, even in ways that are different to their natural function.

Researchers at the university of chicago.

Founded in 1,890, the University of Chicago (UChicago, U of C, or Chicago) is a private research university in Chicago, Illinois. Located on a 217-acre campus in Chicago’s Hyde Park neighborhood, near Lake Michigan, the school holds top-ten positions in various national and international rankings. UChicago is also well known for its professional schools: Pritzker School of Medicine, Booth School of Business, Law School, School of Social Service Administration, Harris School of Public Policy Studies, Divinity School and the Graham School of Continuing Liberal and Professional Studies, and Pritzker School of Molecular Engineering.

Better understanding the formation of swirling, ring-shaped disturbances—known as vortex rings—could help nuclear fusion researchers compress fuel more efficiently, bringing it closer to becoming a viable energy source.

The model developed by researchers at the University of Michigan could aid in the design of the fuel capsule, minimizing the energy lost while trying to ignite the reaction that makes stars shine. In addition, the model could help other engineers who must manage the mixing of fluids after a shock wave passes through, such as those designing supersonic jet engines, as well as physicists trying to understand supernovae.

“These vortex rings move outward from the collapsing star, populating the universe with the materials that will eventually become nebulae, planets and even new stars—and inward during fusion implosions, disrupting the stability of the burning fusion fuel and reducing the efficiency of the reaction,” said Michael Wadas, a doctoral candidate in mechanical engineering at U-M and corresponding author of the study.

University of ChicagoFounded in 1,890, the University of Chicago (UChicago, U of C, or Chicago) is a private research university in Chicago, Illinois. Located on a 217-acre campus in Chicago’s Hyde Park neighborhood, near Lake Michigan, the school holds top-ten positions in various national and international rankings. UChicago is also well known for its professional schools: Pritzker School of Medicine, Booth School of Business, Law School, School of Social Service Administration, Harris School of Public Policy Studies, Divinity School and the Graham School of Continuing Liberal and Professional Studies, and Pritzker School of Molecular Engineering.

(https://isbscience.org/bio/leroy-hood/) is Co-Founder, Chief Strategy Officer and Professor, at the Institute of Systems Biology (ISB) in Seattle, as well as CEO of Phenome Health (https://phenomehealth.org/), a nonprofit organization dedicated to delivering value through health innovation focused on his P4 model of health (Predictive, Preventive, Personalized and Participatory) where a patient’s unique individuality is acknowledged, respected, and leveraged for the benefit of everyone.

Dr. Hood, who is a world-renowned scientist and recipient of the National Medal of Science in 2011, co-founded the Institute for Systems Biology (ISB) in 2000 and served as its first President from 2000–2017. In 2016, ISB affiliated with Providence St. Joseph Health (PSJH) and Dr. Hood became PSJH’s Senior Vice President and Chief Science Officer.

Continue reading “Dr. Leroy Hood, MD, Ph.D. — Co-Founder, Institute of Systems Biology (ISB); CEO, Phenome Health” »

EPFL researchers have created novel protein binders that can seamlessly attach to important targets, including the spike protein of SARS-CoV-2.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the official name of the virus strain that causes coronavirus disease (COVID-19). Previous to this name being adopted, it was commonly referred to as the 2019 novel coronavirus (2019-nCoV), the Wuhan coronavirus, or the Wuhan virus.