Lifeboat Foundation

The new development is promising a potential treatment option for patients with chronic heart failure.

There are over six million patients in the U.S. who suffer from chronic heart failure, and now there is a cell therapy that might help all these patients.

They have proposed a treatment called MPC (mesenchymal precursor cell) therapy.

Continue reading “New cell therapy for chronic heart failure actually works, here is how” »

Experts warn that while the fungal parasite featured in HBO’s popular show “The Last of Us” may only be fictional, the threat from real-life fungal pathogens is on the rise around the world.

Normal body temperature can vary from individual to individual. However, despite this variation, the average basal body temperature of humans has mysteriously dropped since the 1860s. A recent study points to the gut microbiome as a possible contributor to regulating body temperature, both in healthy individuals and during life-threatening infections.

The study, conducted by a team of researchers led by Robert Dickson, M.D., at the University of Michigan Medical School, utilized health records from patients admitted to the hospital with sepsis and conducted experiments on mice to investigate the relationship between the gut bacteria composition, temperature changes, and health outcomes.

Sepsis, the body’s response to a life-threatening infection, can cause drastic changes in body temperature, the trajectory of which is linked to mortality. Previous work has demonstrated that hospitalized patients with sepsis vary widely in their temperature responses, and this variation predicts their survival.

A new study suggests that we may be able to prevent chronic inflammation in multiple sclerosis (MS) patients in a totally new way, by manipulating their gut microbiomes — the unique collection of microbes that live in our digestive tracts and play an important role in our health.

“We are approaching the search for multiple sclerosis therapeutics from a new direction,” said lead researcher Andrea Merchak from the University of Virginia (UVA).

Chronic inflammation: The immune system fights infections and heals injuries by sending inflammatory cells to the site of the problem. This process, inflammation, can cause pain, swelling, or other side effects, but ultimately, it’s for the greater good.

If you’ve got a fever and a cough, you don’t necessarily have to go to the doctor anymore to find out if it’s the flu or Covid-19.

On Friday, the US Food and Drug Administration authorized what it says is the first at-home test that can tell users if they have the flu and/or Covid-19.

The test, made by California biotech company Lucira Health, uses a single self-collected nasal swab and can provide results in about half an hour. The test can be bought without a prescription. It’s authorized for anyone 14 and older for self-collection, or an adult can give it to a child 2 or older.

Cancer is not a uniform disease. Rather, cancer is a disease of phenotypic plasticity, meaning tumor cells can change from one form or function to another. This includes reverting to less mature states and losing their normal function, which can result in treatment resistance, or changing their cell type altogether, which facilitates metastasis.

In addition to direct changes in your DNA in cancer, a key driver of cancer progression is where and when your DNA is activated. If your DNA contains the “words” that spell out individual genes, then epigenetics is the “grammar” of your genome, telling those genes whether they should be turned on or off in a given tissue. Even though all tissues in the body have almost exactly the same DNA sequence, they can all carry out different functions because of chemical and structural modifications that change which genes are activated and how. This “epigenome” can be influenced by environmental exposures such as diet, adding a dimension to how researchers understand drivers of health beyond the DNA code inherited from your parents.

I’m a cancer researcher, and my laboratory at Johns Hopkins University studies how the differences among normal tissues are controlled by an epigenetic code, and how this code is disrupted in cancer. In our recently published review, colleague Andre Levchenko at Yale University and I describe a new approach to understanding cancer plasticity by combining epigenetics with mathematics. Specifically, we propose how the concept of stochasticity can shed light on why cancers metastasize and become resistant to treatments.

A team of biology researchers from Universität der Bundeswehr, Technische Universität München and the University of Cassino and Southern Lazio, has found that people exhale more aerosols when engaging in endurance exercise than they do when engaging in resistance exercise. The study is published in the Proceedings of the National Academy of Sciences.

As the global pandemic has progressed, scientists across the globe have studied various aspects of the SARS-CoV-2 virus spread. One such area of study has been comparison of types of activities that are more or less conducive to transmission of the virus.

In this new study, the researchers looked at exercise options and their related risk. Going to gyms to exercise is a popular way to keep in shape. But doing so can put people at risk from both airborne and surface viral and bacterial infections.

When a person experiences a happy or sad mood, which brain cells are active?

To answer that question, scientists need to understand how individual brain cells contribute to a larger network of brain activity and what role each cell plays in shaping behavior and overall health. Until now, it’s been difficult to get a clear view of how brain cells in living animals behave over extended periods of time.

But Jia Liu’s group at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) has developed an electronic implant that collected detailed information about brain activity from a single cell of interest for more than a year. Their findings, based on research in mice, are reported in Nature Neuroscience.

Psyllium fiber protects against ulcerative colitis and suppresses inflammation by activating the bile acid nuclear receptor, a mechanism that was previously unrecognized, according to a new study by researchers in the Institute for Biomedical Sciences at Georgia State University.

The findings published in the journal Cellular and Molecular Gastroenterology and Hepatology (CMGH) reveal that psyllium, which is semi-soluble and derived from Plantago seeds, inhibits inflammation that can lead to colitis in mice by increasing serum bile acids, resulting in the activation of the farnesoid X receptor (FXR), a bile acid nuclear receptor.

Fiber-rich foods promote intestinal and metabolic health, but the extent of protection varies for each fiber type and the mechanisms that offer this protection are poorly defined. It has been unclear whether dietary fiber can benefit severe forms of intestinal inflammation, such as Crohn’s disease and ulcerative colitis, which are collectively known as inflammatory bowel disease (IBD) and affect 3 million adults in the United States.