Summary: Determining the structure of vitronectin, a protein implicated in age-related macular degeneration and some neurodegenerative disorders, and using pressure to alter the protein shape may help in the development of new treatments for AMD.
Source: Sanford Burnham Prebys.
Research led by Sanford Burnham Prebys professor Francesca Marassi, Ph.D., is helping to reveal the molecular secrets of macular degeneration, which causes almost 90% of all age-related vision loss.
Japan is investing a lot into Longevity Research in hopes of keeping us young forever. And recently, they managed to bring about a new kind of vaccine which…
Senescent macrophages are in fact also found to express senescence-related markers p16(Ink4a) and β-galactosidase (β-gal), and promote inflammation in diseased tissues [25, 26]. Our previous work has indicated increased cellular senescence in dystrophic muscles of mdx/utr(−/−) mice [3], however, whether or not macrophages in particular develop cellular senescence and promote senescence associated phenotypes was still unknown. To this end, here we further examined mdx/utr(−/−) mice and solved these puzzles.
Immune cells in the skeletal muscle are activated during muscle injury and promote the process of muscle regeneration by coordinating with muscle stem cells. However, studies with severely diseased muscles further demonstrate that immune cells can become dominantly activated and is inductive of increased fatty infiltration and fibrosis formation, while at the same time potently repress the proliferation and function of muscle stem cells [27]. Our current results in severely dystrophic muscle reveal a similar situation of interaction between macrophages and MPCs, showing that the function of MPCs is repressed by the senescent macrophages. As senescent cells accumulate in the aged or diseased tissues, it can exert profound effects on the growth and function of normal cells by releasing SASPs [9, 10].
Axolotls Can Regenerate Their Own Brains: New research maps out the different cell types hoping to pave the way to regenerative medicine!
O.o!!!
According to recent research, the protein CHIP can control the insulin receptor more effectively while acting alone than when in a paired state. In cellular stress situations, CHIP often appears as a homodimer – an association of two identical proteins – and mainly functions to destroy misfolded and defective proteins. CHIP thus cleanses the cell. In order to do this, CHIP works with helper proteins to bind a chain of the small protein ubiquitin to misfolded proteins.
As a result, the cell detects and gets rid of defective proteins. Furthermore, CHIP controls insulin receptor signal transduction. CHIP binds to the receptor and degrades it, preventing the activation of life-extending gene products.
Researchers from the University of Cologne have now shown via tests using human cells and the nematode Caenorhabditis elegans that CHIP can also label itself with ubiquitin, preventing the formation of its dimer. The CHIP monomer regulates insulin signaling more effectively than the CHIP dimer. The research was conducted by the University of Cologne’s Cluster of Excellence for Cellular Stress Responses in Aging-Associated Diseases (CECAD) and was recently published in the journal Molecular Cell.
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Article originally published on LINKtoLEADERS under the Portuguese title “Sem saber ler nem escrever!”
In the 80s, “with no knowledge, only intuition”, I discovered the world of computing. I believed computers could do everything, as if it were an electronic God. But when I asked the TIMEX Sinclair 1000 to draw the planet Saturn — I am fascinated by this planet, maybe because it has rings —, I only glimpse a strange message on the black and white TV:
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SINGAPORE — A new longevity clinic where the doctor will diagnose a healthy person’s biological age and then provide a customised plan to slow ageing is being set up at Alexandra Hospital and is expected to open by early next year.
It will be the first publicly funded outpatient clinic in longevity medicine in Singapore and possibly in the world, Professor Andrea Maier, the co-director of the National University Health System (NUHS) Centre for Healthy Longevity told The Straits Times at the sidelines of the centre’s opening on Wednesday.
The clinic will be manned by internal medicine specialists like Prof Maier, who is also the founding president of the International Longevity Medicine Society that was set up last month.
Water is a key ingredient to all life on Earth, yet tardigrades with their near immortal-like powers can somehow endure being sapped of almost all their H2O.
Now, researchers have discovered another trick these chubby microscopic anomalies use to survive years of extreme dehydration.
“Although water is essential to all life we know of, some tardigrades can live without it potentially for decades,” says University of Tokyo biologist Takekazu Kunieda.
Excerpt from an interview by Rich Roll to Peter Diamandis, founder and executive officer of XPrize Foundation, co-founder of Singularity University in Silicon Valley, CA., three-time best selling author, public speaker, philanthropist, and prolific investor.
Peter Diamandis has started over 20 companies in the areas of longevity, space, venture capital and education.
The interview took place in March 14, 2022.
To watch the entire interview clic here: https://youtu.be/gbpzdlib2us