Scientists repurpose an Alzheimer’s drug to enhance the ability of stem cells to repair dental damage in mice. By Diana Kwon | January 10, 2017.
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Category: neuroscience – Page 901
Scientists at the École polytechnique fédérale de Lausanne (EPFL) have found a way to make mitochondria more resistant to damage, which could potentially be used to halt Alzheimer’s and other, similar, diseases.
Globally, Alzheimer’s disease is the most common form of dementia and cause of neurodegeneration. It causes brain damage and symptoms such as long-term memory loss. It is an amyloid-based disease, with the characteristic hallmark being the formation of toxic plaques in the brain made from the aggregated beta-amyloid inside the neurons.
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Biologist Mark Roth, at Seattle’s Fred Hutchinson Cancer Research Center, is working with animal subjects, putting them into suspended animation. The idea is that a patient who is in medical crisis could be put into a suspended state like hibernation, until he or she could be stabilized and in this way, get past it.
Though we tend to expire when the oxygen level is low, many animals go into a suspended state in extremely low oxygen environments. In the lab, one must enter into such an environment quickly. Roth is currently working with nematodes—a kind of roundworm—and expects to eventually work up to humans.
A vegetative state is another aspect of what we consider the gray zone between life and death. Medically, this is when sufficient damage to the brain has occurred, where the person isn’t aware of and can’t respond to their surroundings. They may breathe, have a heartbeat, move their eyes, even show reflexes, but they can’t respond to stimuli or interact with the world. Their brain stem is operating normally, but other parts of the brain may be damaged or inoperable. Most patients who enter such a state never leave it.
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Neuroscientist Marco Iacoboni discusses mirror neurons, autism and the potentially damaging effects of violent movies.
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What is a body other than the vessel for your consciousness? Does the one you’re using right now really matter all that much? Why not, when your current body gets all old and run down, don’t you just get a new, young, beautiful, and healthy one? That’s the pitch in the first trailer for Netflix’s new dystopian sci-fi series Altered Carbon, which takes the form of an advertisement for Psychasec.
“Centuries ago, mankind discovered a way to transfer consciousness into a new body making death a mere inconvenience,” says the commercial. “Since then we’ve been providing an unparalleled pedigree of human sleeves to only the most discerning clientele. Psychasec: Live forever in the body you deserve.”
Based on Richard K. Morgan’s 2002 award-winning cyberpunk novel, Altered Carbon is set hundreds of years in the future when the super rich can repeatedly trade out their bodies (called “sleeves”) to live forever. The new Netflix series follows a soldier/P.I. named Takeshi Kovacs (played by both Will Yun Lee and Joel Kinnman) who wakes up centuries later in a new body to solve the murder of a billionaire.
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Mukherjee is now 47 and lives in New York; Marsh, 67, lives in Oxford. To different extents both of these doctors still practise in their respective fields – Mukherjee at Columbia University’s cancer centre, Marsh as a visiting doctor at various hospitals around the world, including in Kathmandu in Nepal. Both men have continued to write: Marsh a second volume of autobiography, called Admissions, published this year, and Mukherjee a study of genetics called The Gene: An Intimate History, published last year. When they sat down to talk to each other over Skype one Saturday afternoon in November, they began with a subject on which their two lifelong disciplines overlap: the treatment of brain cancer.
The cancer specialist and the neurosurgeon talk about treating cancer, writing and facing death in their own families by Tom Lamont.
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Dr. Hébert will be in Berlin to provide an update on his fascinating work. The use of stem cells to repair the brain is relatively straightforward for Parkinson’s disease, in which cell depletion is localized to one small region, but in Alzheimer’s disease and other conditions, the cell loss is widely distributed, whereas cells can only be injected into one spot. The solution that Dr. Hébert explores is to make those cells migrate before dividing and differentiating.
https://www.undoing-aging.org/dr-jean-hebert-to-speak-at-undoing-aging-2018
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