Lifeboat Foundation

Enter Kim’s class, 2.74 (Bio-Inspired Robotics).

According to Kim, researchers need to understand this cognitive bias, this tendency toward anthropomorphism, in order to even begin developing robots that can help humans with their physical movements. While Kim’s research interest is in building robots that could help people, such as the elderly in an aging population with fewer young people to perform services, such advancement is not even possible without understanding biology, biomechanics, and how much we don’t understand about our own everyday movements.

“One big thing students should learn in this class is not necessarily to understand how we move our body but the fact that we don’t understand how we move,” Kim says. “One of our ultimate goals in robotics is to develop robots that help elderly people by mimicking how we use our arms and legs, but if you don’t realize how little we know about how we move, we cannot even start tackling this problem.”

As biological singularity genes grow so will leisure activities grow and blossom. Even now tricking is a show of the real human potential in movement. Just shows us that the future is much brighter everyday with new activities that push the human potential and humans will have even greater heights of human abilities when the biological singularity genes can make us soar to new abilities.

Sixteen of the best tricking athletes came to Atlanta and battled head to head for the winning title.

Continue reading “Freestyle Tricking Battle | Red Bull Throwdown 2014” »

Inspired by biological fractals, a team of researchers affiliated with multiple institutions in China has developed a new pore structure for a membrane used to separate uranium from seawater. In their paper published in the journal Nature Sustainability, the group describes their pore structure and how well it worked when tested. Alexander Wiechert and Sotira Yiacoumi with the Georgia Institute of Technology and Costas Tsouris with Oak Ridge National Laboratory, have published a News & Views piece on the work done by the team in China and the work that is left to do before the membrane can be commercialized.

In the 1950s, scientists realized that the world’s oceans held the potential for supplying the uranium needed to produce atomic weapons and electrical power. But it took another 30 years before a viable means of extracting uranium was developed. A team of researchers in Japan developed an amidoxime-grafted adsorbent that appeared able to do the job, but only in a limited way. In this new effort, the researchers have expanded on the work by the Japanese team to create a membrane for use in filtering uranium from seawater.

The membrane created by the team in China is based on a hierarchical pore structure that was modeled on fractals found in nature. Seawater containing uranium enters the outer portion of the membrane through macropores. The molecules in the water then migrate into a branching matrix of smaller channels. From there, they are carried to a microporous inner portion of the membrane where the uranium is absorbed by an amidoxime-grafted adsorbent. Testing showed it capable of extracting 9 mg g⁻¹ from a sample of seawater over four weeks.

Year 2021 😀 😍

The COVID-19 pandemic has reached direct and indirect medical and social consequences with a subset of patients who rapidly worsen and die from severe-critical manifestations. As a result, there is still an urgent need to identify prognostic biomarkers and effective therapeutic approaches. Severe-critical manifestations of COVID-19 are caused by a dysregulated immune response. Immune checkpoint molecules such as Programmed death-1 (PD-1) and its ligand programmed death-ligand 1 (PD-L1) play an important role in regulating the host immune response and several lines of evidence underly the role of PD-1 modulation in COVID-19. Here, by analyzing blood sample collection from both hospitalized COVID-19 patients and healthy donors, as well as levels of PD-L1 RNA expression in a variety of model systems of SARS-CoV-2, including in vitro tissue cultures, ex-vivo infections of primary epithelial cells and biological samples obtained from tissue biopsies and blood sample collection of COVID-19 and healthy individuals, we demonstrate that serum levels of PD-L1 have a prognostic role in COVID-19 patients and that PD-L1 dysregulation is associated to COVID-19 pathogenesis. Specifically, PD-L1 upregulation is induced by SARS-CoV-2 in infected epithelial cells and is dysregulated in several types of immune cells of COVID-19 patients including monocytes, neutrophils, gamma delta T cells and CD4+ T cells. These results have clinical significance since highlighted the potential role of PD-1/PD-L1 axis in COVID-19, suggest a prognostic role of PD-L1 and provide a further rationale to implement novel clinical studies in COVID-19 patients with PD-1/PD-L1 inhibitors.

COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) holds the world in thrall since early March 2020. COVID-19 manifests a spectrum of signs and symptoms from mild illness to acute pneumonia. Unfortunately, a considerable percentage of patients rapidly worse to acute respiratory distress syndrome (ARDS) requiring intensive care (1, 2).

Continue reading “PD-L1 Dysregulation in COVID-19 Patients” »

Autonomous Microscopy powered by Aivia enables scientists to discover more by extracting the most relevant data from their experiments.

06 June 2023, Wetzlar, Germany - Leica Microsystems, a leader in microscopy and scientific instrumentation, has launched Autonomous Microscopy powered by Aivia. This new AI-based detection workflow for confocal microscopy automates the detection of rare events. It follows what the user has defined as the objects of interest that will trigger the rare event scan. Users benefit from the potential to discover more by automatically detecting up to 90% of rare events during an experiment. By focusing on the data that matter during the acquisition process itself, time to result can be reduced by up to 70%. The Aivia-powered workflow reduces time spent at the microscope by up to 75%, leading to increased productivity to do more.

“Autonomous Microscopy powered by Aivia brings the power of Artificial Intelligence to everyday experimental environments in an easy-to-use way,” says James O’Brien, Vice President of Life Sciences and Applied Microscopy at Leica Microsystems. “Researchers can now establish confocal microscopy workflows that address advanced experiments and biological questions that would be impossible or very laborious without automated procedures. This solution gives them outstanding new options to obtain results that answer their research questions.”

Biologists are finally beginning to corral molecules, cells and whole organisms to carry out complex computations. These living processors could find use in everything from smart materials to new kinds of artificial intelligence.

By Edd Gent

A two-year expedition to coral reefs in the Pacific Ocean detected half a million types of microbes, the latest estimate in the quest to quantify the planet’s microbiome.

The big picture: There is intense debate among scientists about how many different types of bacteria and other microorganisms live on Earth — information that could aid conservation of species and fragile ecosystems brimming with biodiversity.

The mammalian retina is a complex system consisting out of cones (for color) and rods (for peripheral monochrome) that provide the raw image data which is then processed into successive layers of neurons before this preprocessed data is sent via the optical nerve to the brain’s visual cortex. In order to emulate this system as closely as possible, researchers at Penn State University have created a system that uses perovskite (methylammonium lead bromide, MAPbX₃) RGB photodetectors and a neuromorphic processing algorithm that performs similar processing as the biological retina.

Panchromatic imaging is defined as being ‘sensitive to light of all colors in the visible spectrum’, which in imaging means enhancing the monochromatic (e.g. RGB) channels using panchromatic (intensity, not frequency) data. For the retina this means that the incoming light is not merely used to determine the separate colors, but also the intensity, which is what underlies the wide dynamic range of the Mark I eyeball. In this experiment, layers of these MAPbX₃ (X being Cl, Br, I or combination thereof) perovskites formed stacked RGB sensors.

The output of these sensor layers was then processed in a pretrained convolutional neural network, to generate the final, panchromatic image which could then be used for a wide range of purposes. Some applications noted by the researchers include new types of digital cameras, as well as artificial retinas, limited mostly by how well the perovskite layers scale in resolution, and their longevity, which is a long-standing issue with perovskites. Another possibility raised is that of powering at least part of the system using the energy collected by the perovskite layers, akin to proposed perovskite-based solar panels.

Quantum effects are phenomena that occur between atoms and molecules that can’t be explained by classical physics. It has been known for more than a century that the rules of classical mechanics, like Newton’s laws of motion, break down at atomic scales. Instead, tiny objects behave according to a different set of laws known as quantum mechanics.

For humans, who can only perceive the macroscopic world, or what’s visible to the naked eye, quantum mechanics can seem counterintuitive and somewhat magical. Things you might not expect happen in the quantum world, like electrons “tunneling” through tiny energy barriers and appearing on the other side unscathed or being in two different places at the same time in a phenomenon called superposition.

I am trained as a quantum engineer. Research in quantum mechanics is usually geared toward technology. However, and somewhat surprisingly, there is increasing evidence that nature – an engineer with billions of years of practice — has learned how to use quantum mechanics to function optimally. If this is indeed true, it means that our understanding of biology is radically incomplete. It also means that we could possibly control physiological processes by using the quantum properties of biological matter.