Lifeboat Foundation

New research shows that cells understand and execute directions correctly, and scientists may be able to take advantage.

By hijacking the DNA of a human cell, they showed it’s possible to program it like a simple computer.

A new powerful drug reverses ageing in mice.

Robots continue to be awesome. #RoboticSurgery

World-first transplant to treat macular degeneration could augur rise of iPS cell banks.

• By David Cyranoski, Nature on March 29, 2017

One of the best-known regions of the brain, the cerebellum accounts for just 10 percent of the organ’s total volume, but contains more than 50 percent of its neurons.

Despite all that processing power, it’s been assumed that the cerebellum functions largely outside the realm of conscious awareness, instead coordinating physical activities like standing and breathing. But now neuroscientists have discovered that it plays an important role in the reward response — one of the main drives that motivate and shape human behaviour.

Not only does this open up new research possibilities for the little region that has for centuries been primarily linked motor skills and sensory input, but it suggests that the neurons that make up much of the cerebellum — called granule cells — are functioning in ways we never anticipated.

Continue reading “Neuroscientists Have Accidentally Discovered a Whole New Role for the Cerebellum” »

Where in the human body is blood created?

Another biomarker of senescent cells could be p16, a protein whose levels increase when cells stop dividing if old and also a protein whose gene is turned off in many human cancers.

Coming back to our topic – designing senolytics that avoid the apoptosis of young, healthy cells – the ideal senolytic should accomplish two things: –turn on p53 at increased levels to determine stubborn, senescent cells to commit suicide –do that on senescent cells only.

And in order to accomplish the second part, such a drug should be ‘programmed’ to only act on those cells where it recognizes senescence-associated biomarkers. There is no single biomarker today that stains positive or negative on all types of senescence cells, but increased levels of beta-galactosidase and p16 proteins could be a welcome start to identify old cells in vivo when designing such a drug.

Continue reading “How to avoid the adverse reactions of senolytics through better design” »

A counter to the recent John Hopkins study which some media have interpreted as cancer being mostly due to bad luck which we shared earlier today.

And in the interest of comparison this article presents the other side of the argument and counters the John Hopkins study we reported on earlier today.

Genomic instability (mutations) has been suggested as being one of the primary hallmarks of aging and this research might support that idea. Researchers at John Hopkins report that around 66% of mutations in cancer cells are due to random errors with environment/lifestyle contributing 29% and 5% inherited.

“That finding challenges the common wisdom that cancer is the product of heredity and the environment. “There’s a third cause and this cause of mutations is a major cause,” says cancer geneticist Bert Vogelstein.”

“Such random mutations build up over time and help explain why cancer strikes older people more often. Knowing that the enemy will strike from within even when people protect themselves against external threats indicates that early cancer detection and treatment deserve greater attention than they have previously gotten, Vogelstein says.”

Continue reading “Random mutations play large role in cancer, study finds” »