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Archive for the ‘genetics’ category: Page 498

May 8, 2015

Chinese scientists genetically modify human embryos

Posted by in categories: biological, biotech/medical, genetics

David Cyranosk & Sara Reardon  - Nature.com

In a world first, Chinese scientists have reported editing the genomes of human embryos. The results are published1 in the online journal Protein & Cell and confirm widespread rumours that such experiments had been conducted — rumours that sparked a high-profile debate last month2, 3 about the ethical implications of such work. Read more

Mar 14, 2015

Engineering the Perfect Baby

Posted by in categories: DNA, genetics

By Antonio Regalado — MIT Technology Review

If anyone had devised a way to create a genetically engineered baby, I figured George Church would know about it.

At his labyrinthine laboratory on the Harvard Medical School campus, you can find researchers giving E. Coli a novel genetic code never seen in nature. Around another bend, others are carrying out a plan to use DNA engineering to resurrect the woolly mammoth. His lab, Church likes to say, is the center of a new technological genesis—one in which man rebuilds creation to suit himself.
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Mar 3, 2015

Is DNA the Language of the Book of Life?

Posted by in categories: DNA, genetics

Posted By Regan Penaluna — Nautilus
GATTACA is here
When we talk about genes, we often use expressions inherited from a few influential geneticists and evolutionary biologists, including Francis Crick, James Watson, and Richard Dawkins. These expressions depict DNA as a kind of code telling bodies how to form. We speak about genes similarly to how we speak about language, as symbolic and imbued with meaning. There is “gene-editing,” and there are “translation tables” for decoding sequences of nucleic acid. When DNA replicates, it is said to “transcribe” itself. We speak about a message—such as, build a tiger! or construct a female!—being communicated between microscopic materials. But this view of DNA has come with a price, argue some thinkers. It is philosophically misguided, they say, and has even led to scientific blunders. Scratch the surface of this idea, and below you’ll find a key contradiction.

Since the earliest days of molecular biology, scientists describe genetic material to be unlike all other biological material, because it supposedly carries something that more workaday molecules don’t: information. In a 1958 paper, Crick presented his ideas on the importance of proteins for inheritance, and said that they were composed of energy, matter, and information. Watson called DNA the “repository” of information.
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Feb 25, 2015

Researchers generate a reference map of the human epigenome

Posted by in categories: DNA, genetics

Helen Knight | MIT News correspondent
Manolis Kellis
The sequencing of the human genome laid the foundation for the study of genetic variation and its links to a wide range of diseases. But the genome itself is only part of the story, as genes can be switched on and off by a range of chemical modifications, known as “epigenetic marks.”

Now, a decade after the human genome was sequenced, the National Institutes of Health’s Roadmap Epigenomics Consortium has created a similar map of the human epigenome.
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Jan 4, 2015

New Book: An Irreverent Singularity Funcyclopedia, by Mondo 2000’s R.U. Sirius.

Posted by in categories: 3D printing, alien life, automation, big data, bionic, bioprinting, biotech/medical, complex systems, computing, cosmology, cryptocurrencies, cybercrime/malcode, cyborgs, defense, disruptive technology, DNA, driverless cars, drones, economics, electronics, encryption, energy, engineering, entertainment, environmental, ethics, existential risks, exoskeleton, finance, first contact, food, fun, futurism, general relativity, genetics, hacking, hardware, human trajectories, information science, innovation, internet, life extension, media & arts, military, mobile phones, nanotechnology, neuroscience, nuclear weapons, posthumanism, privacy, quantum physics, robotics/AI, science, security, singularity, software, solar power, space, space travel, supercomputing, time travel, transhumanism

Quoted: “Legendary cyberculture icon (and iconoclast) R.U. Sirius and Jay Cornell have written a delicious funcyclopedia of the Singularity, transhumanism, and radical futurism, just published on January 1.” And: “The book, “Transcendence – The Disinformation Encyclopedia of Transhumanism and the Singularity,” is a collection of alphabetically-ordered short chapters about artificial intelligence, cognitive science, genomics, information technology, nanotechnology, neuroscience, space exploration, synthetic biology, robotics, and virtual worlds. Entries range from Cloning and Cyborg Feminism to Designer Babies and Memory-Editing Drugs.” And: “If you are young and don’t remember the 1980s you should know that, before Wired magazine, the cyberculture magazine Mondo 2000 edited by R.U. Sirius covered dangerous hacking, new media and cyberpunk topics such as virtual reality and smart drugs, with an anarchic and subversive slant. As it often happens the more sedate Wired, a watered-down later version of Mondo 2000, was much more successful and went mainstream.”


Read the article here >https://hacked.com/irreverent-singularity-funcyclopedia-mondo-2000s-r-u-sirius/

Jan 2, 2015

The Immortalists Official Trailer

Posted by in categories: biological, biotech/medical, genetics, human trajectories, life extension

Dec 30, 2014

The Blockchain is the New Database, Get Ready to Rewrite Everything

Posted by in categories: architecture, automation, big data, bitcoin, business, complex systems, computing, cryptocurrencies, cyborgs, defense, disruptive technology, economics, education, encryption, engineering, finance, futurism, genetics, geopolitics, governance, government, hacking, hardware, human trajectories, information science, internet, law, military, mobile phones, nanotechnology, neuroscience, open access, open source, philosophy, physics, privacy, robotics/AI, science, scientific freedom, security, singularity, software, strategy, supercomputing, transhumanism, transparency

Quoted: “If you understand the core innovations around the blockchain idea, you’ll realize that the technology concept behind it is similar to that of a database, except that the way you interact with that database is very different.

The blockchain concept represents a paradigm shift in how software engineers will write software applications in the future, and it is one of the key concepts behind the Bitcoin revolution that need to be well understood. In this post, I’d like to explain 5 of these concepts, and how they interrelate to one another in the context of this new computing paradigm that is unravelling in front of us. They are: the blockchain, decentralized consensus, trusted computing, smart contracts and proof of work / stake. This computing paradigm is important, because it is a catalyst for the creation of decentralized applications, a next-step evolution from distributed computing architectural constructs.

Screen Shot 2014-12-23 at 10.30.59 PM

Read the article here > http://startupmanagement.org/2014/12/27/the-blockchain-is-th…verything/

Oct 13, 2014

2014 Longevity and Genetics Conference – Keynote Aubrey de Grey

Posted by in categories: biological, biotech/medical, DNA, events, genetics, life extension, science

Western Canada’s most futurist-oriented longevity organization, the Lifespan Society of British Columbia, has organized a first-class life extension conference, which will take place later this fall in the heart of downtown Vancouver. The Longevity and Genetics Conference 2014 offers a full-day of expert presentations, made accessible to a general audience, with keynote on the latest developments in biorejuvination by Aubrey de Grey of SENS Research Foundation. The conference will be interactive, with a panel session for audience questions, and VIP options for further interaction with speakers.

ImageofAubreydeGrey

Aubrey de Grey

Who will be there? In addition to Aubrey de Grey, there are four other speakers confirmed thus far: Dr. Angela Brooks-Wilson, Head of Cancer Genetics at the Michael Smith Genome Sciences Centre at the BC Cancer Agency, Dr. S. Jay Olshansky, Board of Directors of the American Federation of Aging Research, and co-author of The Quest for Immortality: Science at the Frontiers of Aging, Dr. Clinton Mielke, former Mayo Clinic researcher and founder of the quantified self platform “infino.me”, and lastly, one of futurism’s most experienced and dedicated radical longevity advocates, Benjamin Best, who is currently Director of Research Oversight at the Life Extension Foundation. This conference is a multi-disciplinary event, engaging several points of interest and relevance in the longevity space, from the cellular, genetic science of aging, to the latest epidemiological and even demographic research. You can also expect discussion on personalized medicine and quantified self technologies, as well as big picture, sociological and philosophical, longevity-specific topics.

All around, the 2014 Longevity and Genetics conference, set to take place Saturday November 15, has a lot to offer, as does the host city of Vancouver. A recent study has indicated that a majority of Canadians, 59%, are in favor of life extension technology, with 47% expecting that science and technology will enable living until 120 by 2050. The Lifespan Society of British Columbia is keeping that momentum and enthusiasm alive and growing, and I’m glad they have organized such a high-calliber event. Tickets are currently still available. Learn more about the event and purchase tickets here.

ImageofVancouver

Vancouver B.C.

Oct 1, 2014

The Abolition of Medicine as a Goal for Humanity 2.0

Posted by in categories: biological, bionic, biotech/medical, ethics, futurism, genetics, homo sapiens, human trajectories, life extension, philosophy, policy, transhumanism

What follows is my position piece for London’s FutureFest 2013, the website for which no longer exists.

Medicine is a very ancient practice. In fact, it is so ancient that it may have become obsolete. Medicine aims to restore the mind and body to their natural state relative to an individual’s stage in the life cycle. The idea has been to live as well as possible but also die well when the time came. The sense of what is ‘natural’ was tied to statistically normal ways of living in particular cultures. Past conceptions of health dictated future medical practice. In this respect, medical practitioners may have been wise but they certainly were not progressive.

However, this began to change in the mid-19th century when the great medical experimenter, Claude Bernard, began to champion the idea that medicine should be about the indefinite delaying, if not outright overcoming, of death. Bernard saw organisms as perpetual motion machines in an endless struggle to bring order to an environment that always threatens to consume them. That ‘order’ consists in sustaining the conditions needed to maintain an organism’s indefinite existence. Toward this end, Bernard enthusiastically used animals as living laboratories for testing his various hypotheses.

Historians identify Bernard’s sensibility with the advent of ‘modern medicine’, an increasingly high-tech and aspirational enterprise, dedicated to extending the full panoply of human capacities indefinitely. On this view, scientific training trumps practitioner experience, radically invasive and reconstructive procedures become the norm, and death on a physician’s watch is taken to be the ultimate failure. Humanity 2.0 takes this way of thinking to the next level, which involves the abolition of medicine itself. But what exactly would that mean – and what would replace it?

Continue reading “The Abolition of Medicine as a Goal for Humanity 2.0” »

Sep 29, 2014

Towards a ‘Right to Science’

Posted by in categories: ethics, genetics, government, law, philosophy, policy, science

In 1906 the great American pragmatist philosopher William James delivered a public lecture entitled, ‘The Moral Equivalent of War’. James imagined a point in the foreseeable future when states would rationally decide against military options to resolve their differences. While he welcomed this prospect, he also believed that the abolition of warfare would remove an important pretext for people to think beyond their own individual survival and toward some greater end, perhaps one that others might end up enjoying more fully. What then might replace war’s altruistic side?

It is telling that the most famous political speech to adopt James’ title was US President Jimmy Carter’s 1977 call for national energy independence in response to the Arab oil embargo. Carter characterised the battle ahead as really about America’s own ignorance and complacency rather than some Middle Eastern foe. While Carter’s critics pounced on his trademark moralism, they should have looked instead to his training as a nuclear scientist. Historically speaking, nothing can beat a science-led agenda to inspire a long-term, focused shift in a population’s default behaviours. Louis Pasteur perhaps first exploited this point by declaring war on the germs that he had shown lay behind not only human and animal disease but also France’s failing wine and silk industries. Moreover, Richard Nixon’s ‘war on cancer’, first declared in 1971, continues to be prosecuted on the terrain of genomic medicine, even though arguably a much greater impact on the human condition could have been achieved by equipping the ongoing ‘war on poverty’ with comparable resources and resoluteness.

Science’s ability to step in as war’s moral equivalent has less to do with whatever personal authority scientists command than with the universal scope of scientific knowledge claims. Even if today’s science is bound to be superseded, its import potentially bears on everyone’s life. Once that point is understood, it is easy to see how each person could be personally invested in advancing the cause of scientific research. In the heyday of the welfare state, that point was generally understood. Thus, in The Gift Relationship, perhaps the most influential work in British social policy of the past fifty years, Richard Titmuss argued, by analogy with voluntary blood donation, that citizens have a duty to participate as research subjects, but not because of the unlikely event that they might directly benefit from their particular experiment. Rather, citizens should participate because they would have already benefitted from experiments involving their fellow citizens and will continue to benefit similarly in the future.

However, this neat fit between science and altruism has been undermined over the past quarter-century on two main fronts. One stems from the legacy of Nazi Germany, where the duty to participate in research was turned into a vehicle to punish undesirables by studying their behaviour under various ‘extreme conditions’. Indicative of the horrific nature of this research is that even today few are willing to discuss any scientifically interesting results that might have come from it. Indeed, the pendulum has swung the other way. Elaborate research ethics codes enforced by professional scientific bodies and university ‘institutional review boards’ protect both scientist and subject in ways that arguably discourage either from having much to do with the other. Even defenders of today’s ethical guidelines generally concede that had such codes been in place over the past two centuries, science would have progressed at a much slower pace.

The other and more current challenge to the idea that citizens have a duty to participate in research comes from the increasing privatisation of science. If a state today were to require citizen participation in drug trials, as it might jury duty or military service, the most likely beneficiary would be a transnational pharmaceutical firm capable of quickly exploiting the findings for profitable products. What may be needed, then, is not a duty but a right to participate in science. This proposal, advanced by Sarah Chan at the University of Manchester’s Institute for Bioethics, looks like a slight shift in legal language. But it is the difference between science appearing as an obligation and an opportunity for the ordinary citizen. In the latter case, one does not simply wait for scientists to invite willing subjects. Rather, potential subjects are invited to organize themselves and lobby the research community with their specific concerns. In our recent book, The Proactionary Imperative, Veronika Lipinska and I propose the concept of ‘hedgenetics’ to capture just this prospect for those who share socially relevant genetic traits. It may mean that scientists no longer exert final control over their research agenda, but the benefit is that they can be assured of steady public support for their work.