Lifeboat Foundation

Researchers at the University of Houston are working to make T-cell immunotherapy safer, developing a tool called CrossDome, which uses a combination of genetic and biochemical information to predict if T-cell immunotherapies might mistakenly attack healthy cells.

T-cell based immunotherapies hold tremendous potential in the fight against cancer and infectious diseases, thanks to their capacity to specifically target diseased cells, including cancer metastasis. Nevertheless, this potential has been tempered with safety concerns regarding the possible recognition of unknown off targets displayed by healthy cells.

In one case, scientists created special T-cells that were supposed to target a protein found in a type of skin cancer called melanoma. However, these T-cells also ended up attacking a different protein found in the heart cells of some patients. This caused severe damage to the heart.

A team of researchers in the United States and United Kingdom say they have created the world’s first synthetic human embryo-like structures from stem cells, bypassing the need for eggs and sperm.

These embryo-like structures are at the very earliest stages of human development: They don’t have a beating heart or a brain, for example. But scientists say they could one day help advance the understanding of genetic diseases or the causes of miscarriages.

The research raises critical legal and ethical questions, and many countries, including the US, don’t have laws governing the creation or treatment of synthetic embryos.

Type 2 diabetes is a significant global health concern, affecting millions of individuals worldwide. The disease is associated with numerous complications, as well as an increased risk of premature mortality. Recent research conducted by the University of Sydney has shed light on the potential of physical activity in preventing the onset of type 2 diabetes, even in individuals with a high genetic risk for the disease [1]. This study underscores the importance of exercise as a key strategy for chronic disease prevention and offers promising news for individuals seeking to reduce their risk of developing type 2 diabetes.

Longevity. Technology: The worldwide burden of type 2 diabetes is substantial, and the disease carries significant implications for public health. Type 2 diabetes is associated with various complications, including cardiovascular diseases, kidney problems and nerve damage. Moreover, individuals with type 2 diabetes often experience a shortened lifespan and reduced healthspan due to the increased risk of developing other chronic conditions. The study’s findings add to the clarion call for effective prevention strategies that alleviate this burden on individuals, families and healthcare systems worldwide.

The research, published in the British Journal of Sports Medicine, involved 59,325 adults enrolled in the UK Biobank project. Participants wore accelerometers on their wrists to measure their physical activity levels and the researchers also considered genetic markers associated with a higher risk of type 2 diabetes. The study followed the participants for up to seven years to assess their health outcomes.

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Exploring Mitochondrial Bioenergetics, Optogenetics, Human Health And Aging — Dr. Brandon Berry, Ph.D., University of Washington.

Dr. Brandon Berry, Ph.D. (https://halo.dlmp.uw.edu/people/brandon-berry/) is a postdoctoral researcher in the Kaeberlein Laboratory at University of Washington where his research focuses on how aging and metabolism are linked.

Continue reading “Dr Brandon Berry, PhD — Exploring Mitochondrial Bioenergetics, Optogenetics, Human Health And Aging” »

For the first time, researchers from Tel Aviv University have developed a genome-scale technology that makes it possible to reveal the role of genes and traits in plants previously hidden by functional redundancy.

The researchers point out that since the agricultural revolution, man has improved plant varieties for agricultural purposes by creating genetic diversity. But until this recent development, it was only possible to examine the functions of single genes, which make up only 20% of the genome. For the remaining 80% of the genome, made up of genes grouped in families, there was no effective way, on the large scale of the whole genome, to determine their role in the plant.

As a result of this unique development, the team of researchers managed to isolate and identify dozens of new features that had been overlooked until now. The development is expected to revolutionize the way agricultural crops are improved as it can be applied to most crops and agricultural traits, such as increased yield and resistance to drought or pests.

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Researchers at the University at Albany’s RNA Institute have demonstrated a new approach to DNA nanostructure assembly that does not require magnesium. The method improves the biostability of the structures, making them more useful and reliable in a range of applications. The work appears in the journal Small this month.

When we think of DNA, the first association that comes to mind is likely genetics—the double helix structure within cells that houses an organism’s blueprint for growth and reproduction. A rapidly evolving area of DNA research is that of DNA nanostructures—synthetic molecules made up of the same building blocks as the DNA found in living cells, which are being engineered to solve critical challenges in applications ranging from medical diagnostics and drug delivery to materials science and data storage.

“In this work, we assembled DNA nanostructures without using magnesium, which is typically used in this process but comes with challenges that ultimately reduce the utility of the nanostructures that are produced,” said Arun Richard Chandrasekaran, corresponding author of the study and senior research scientist at the RNA Institute.

Summary: Researchers discovered sequence variants in the gene ABCC9 that influence voice pitch.

Utilizing speech recordings from nearly 13,000 Icelanders and corresponding genomic data, the scientists identified common ABCC9 variants associated with higher voice pitch in both men and women. Additionally, these variants were linked to higher pulse pressure, revealing intriguing connections between voice pitch and health.

The study also uncovered a heritable component in vowel acoustics, enhancing our understanding of the human vocal system.