Lifeboat Foundation

While new technologies, including those powered by artificial intelligence, provide innovative solutions to a steadily growing range of problems, these tools are only as good as the data they’re trained on. In the world of molecular biology, getting high-quality data from tiny biological systems while they’re in motion – a critical step for building next-gen tools – is something like trying to take a clear picture of a spinning propeller. Just as you need precise equipment and conditions to photograph the propeller clearly, researchers need advanced techniques and careful calculations to measure the movement of molecules accurately.

Matthew Lew, associate professor in the Preston M. Green Department of Electrical & Systems Engineering in the McKelvey School of Engineering at Washington University in St. Louis, builds new imaging technologies to unravel the intricate workings of life at the nanoscale. Though they’re incredibly tiny – 1,000 to 100,000 times smaller than a human hair – nanoscale biomolecules like proteins and DNA strands are fundamental to virtually all biological processes.

Scientists rely on ever-advancing microscopy methods to gain insights into these systems work. Traditionally, these methods have relied on simplifying assumptions that overlook some complexities of molecular behavior, which can be wobbly and asymmetric. A new theoretical framework developed by Lew, however, is set to shake up how scientists measure and interpret wobbly molecular motion.

For roughly 70 years, Play-Doh has been entertaining children with its moldable, squishy form. This familiar substance belongs to a broader category known as soft matter, which includes some foods (such as mayonnaise), 3D printer gels, battery electrolytes and latex paint.

High-precision 3D micro-/nanofabrication technologies such as two-photon polymerization are limited to photocurable polymers. Here, the authors report a “capillary-trapping” strategy to fabricate various 3D micro-scaffolds composed of different nanomaterials.

Single-photon detectors built from superconducting nanowires have become a vital tool for quantum information processing, while their superior speed and sensitivity have made them an appealing option for low-light imaging applications such as space exploration and biophotonics. However, it has proved difficult to build high-resolution cameras from these devices because the cryogenically cooled detectors must be connected to readout electronics operating at room temperature. Now a research team led by Karl Berggren at the Massachusetts Institute of Technology has demonstrated a superconducting electronics platform that can process the single-photon signals at ultracold temperatures, providing a scalable pathway for building megapixel imaging arrays [1].

The key problem with designing high-resolution cameras based on these superconducting detectors is that each of the sensors requires a dedicated readout wire to record the single-photon signals, which adds complexity and heat load to the cryogenic system. Researchers have explored various multiplexing techniques to reduce the number of connections to individual detectors, yielding imaging arrays in the kilopixel range, but further scaling will likely require a signal-processing solution that can operate at ultralow temperatures.

Berggren and his collaborators believe that the answer lies in devices called nanocryotrons (nTrons), which are three-terminal structures made from superconducting nanowires, just like the single-photon detectors are. Although nTrons do not deliver the same speed and power of superconducting electronics based on Josephson junctions, the researchers argue that these shortcomings are not a critical problem in photon-sensing applications, where the detectors are similarly limited in speed and power. The nTrons also offer several advantages over Josephson junctions: they operate over a wider range of cryogenic temperatures, they don’t require magnetic shielding, and they exploit the same fabrication process as that used for the detectors, allowing for easy on-chip integration.

Google scientists have modelled a fragment of the human brain at nanoscale resolution, revealing cells with previously undiscovered features.

We are constantly surrounded by electromagnetic waves such as Wi-Fi and Bluetooth signals. What if we could turn the unused excess into usable energy? Researchers at Tohoku University, the National University of Singapore, and the University of Messina developed a novel technology to efficiently harvest ambient low-power radiofrequency (RF) signals into direct-current (DC) power. This ‘rectifier’ technology can be easily integrated into energy harvesting modules to power electronic devices and sensors, enabling battery-free operation.

The results were published in Nature Electronics (“Nanoscale spin rectifiers for harvesting ambient radiofrequency energy”).

Schematic illustration of a wireless network with energy-harvesting modules. RF signals that are unused by electronic gadgets and would otherwise go to waste are used to generate usable DC power to drive sensors and devices. (Image: Shunsuke Fukami & Hyunsoo Yang)

Nanoelectronics.

This new feature in Nano TV will present the best of science and technology in a short format, which is easy to understand and also appreciate the beauty of scientific knowledge. Catering to all, these shorts will be informative and educative. Explore science, explore Nanotechnology through our latest series called Nano Shorts.

Continue reading “Nanotechnology in Electronics” »

A new quantum sensor developed by researchers from Korea and Germany can measure magnetic fields at the atomic scale with high precision. This technology uses a single molecule for detection, offering superior resolution and the potential for significant advancements in quantum materials and molecular systems analysis.

In a scientific breakthrough, an international research team from Korea’s IBS Center for Quantum Nanoscience (QNS) and Germany’s Forschungszentrum Jülich developed a quantum sensor capable of detecting minute magnetic fields at the atomic length scale. This pioneering work realizes a long-held dream of scientists: an MRI-like tool for quantum materials.

“You have to be small to see small.” —

ACE, a groundbreaking DNA-powered signal amplification technology, significantly enhances the sensitivity of mass cytometry, providing new insights into various biological and pathological processes.

Since the 1950s, researchers have employed “flow cytometry,” a renowned technique devised by Wallace Coulter, to characterize various types of immune cells in research studies and human blood samples. This method has significantly enhanced our understanding of immune cell development and provided innovative approaches for evaluating human health and diagnosing various blood cancers. Eventually, flow cytometry was extended to analyze other cell types as well.

In traditional flow cytometry, cell surface and intracellular proteins are detected with antibody molecules that are linked to fluorescent probes. However, while providing single-cell sensitivity, this method is limited in detecting multiple proteins by the number of fluorophores that can be clearly distinguished within the entire spectrum of fluorescent light.