Lifeboat Foundation

A tiny bubble popping within a liquid seems more fanciful than traumatic. But millions of popping vapor bubbles can cause significant damage to rigid structures like boat propellers or bridge supports. Can you imagine the damage such bubbles could do to soft human tissues like the brain? During head impacts and concussions, vapor bubbles form and violently collapse, creating damage to human tissue. Purdue University fluid mechanics researchers are now one step closer to understanding these phenomena.

“When a bubble collapses inside a liquid, it generates pressure shock waves,” said Hector Gomez, professor of mechanical engineering and principal investigator. “The process of forming a vapor cavity and its collapse is what we call cavitation.”

“Cavitation has been studied since the 1800s,” said Pavlos Vlachos, the St. Vincent Health Professor of Healthcare Engineering and director of the Regenstrief Center for Healthcare Engineering. “It’s a very complex field of study because it involves non-equilibrium thermodynamics, continuum mechanics, and many other factors on a scale of micrometers and microseconds. After hundreds of years of research, we are only just now starting to understand these phenomena.”

The groundbreaking research that established the connection between Alzheimer’s.

Alzheimer’s disease is a disease that attacks the brain, causing a decline in mental ability that worsens over time. It is the most common form of dementia and accounts for 60 to 80 percent of dementia cases. There is no current cure for Alzheimer’s disease, but there are medications that can help ease the symptoms.

A discovery made by researchers at the University of California, Irvine on how a certain protein is activated in tumor cells may lead to more effective treatments for some of the most deadly types of cancer. The finding, which was led by scientists at the School of Biological Sciences, may potentially result in treatment options for the especially dangerous melanoma and pancreatic adenocarcinoma, as well as the most common type of childhood brain cancer and adult skin cancer. The study was published in the journal Life Science Alliance.

The GLI1 protein, which is essential for cell development but has also been linked to a number of cancers, was the subject of the finding. The Hedgehog signaling pathway, also known as HH, usually activates GLI1. However, scientists have known for almost a decade that crosstalk, or interaction, between HH and the mitogen-activated protein kinase pathway, has a role in cancer.

“In some cases, proteins in one pathway can turn on proteins in another,” said lead author A. Jane Bardwell, a project scientist in UCI’s Department of Developmental and Cell Biology. “It’s a complex system. We wanted to understand the molecular mechanism that leads to GLI1 being activated by proteins in the MAPK pathway.”

The soft, polymer material acts like a brain, simultaneously sensing, thinking, and acting.

Boosting neuron production could be a viable strategy for treating AD patients.

Summary: Researchers at the Human Brain Project have identified and mapped 7 new areas of the insular cortex.

Source: Human Brain Project.

All newly detected areas are now available as 3D probability maps in the Julich Brain Atlas, and can be openly accessed via the HBP’s EBRAINS infrastructure.

Summary: Dampening retromer activity slows down the trafficking of tau in neurodegenerative disorders, a new study reports.

Source: EPFL

Neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease are associated with atypical proteins that form tangles in the brain, killing neurons. Neurobiologists at EPFL have now identified some key mechanisms underlying the formation of these tangles.

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Dr. Max More is a philosopher, writer, speaker and expert in Cryonics — the process of cryopreserving a body at the time of legal death in the hopes of reviving them in the future.

Theo talks with Dr. More about what actually happens when we die, the future of mankind, and if Theo would preserve his brain for science.

Continue reading “Dr. Max More | This Past Weekend w/ Theo Von #404” »