UNC School of Medicine scientists unveiled how a particular gene helps organize the scaffolding of brain cells called radial progenitors necessary for the orderly formation of the brain. Previous studies have shown that this gene is mutated in some people with autism.
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In experiments on pig organs, scientists at Yale made a discovery that could someday challenge our understanding of what it means to die.
Credit credit thomas prior for the new york times.
Blood flows into the brain primarily via the carotid arteries and the vertebral arteries. The Circle of Willis is a circular arterial structure in the brain that connects blood flowing in from the carotid arteries with blood flowing in from the basilar artery (which is fed by the vertebral arteries). Blood flows from the Circle of Willis into brain tissue via the anterior, middle, and posterior cerebral arteries. Many studies have shown that the Circle of Willis is incomplete in most people. A 1998 study of 150 healthy adult volunteers showed a complete Circle of Willis in only 42% of cases — more often complete in younger persons and females [RADIOLOGY; Krabbe-Hartkamp, MJ; 207:103–111 (1998)]. A slightly more encouraging 2002 study of 118 healthy volunteers in the 65–68 age group, showed 47% had a complete Circle of Willis [THE JOURNAL OF CARDIOVASCULAR SURGERY; Macchi, C; 43:887–890 (2002)]
For cryonics purposes, it has been believed that perfusion into the carotid arteries, but not into the vertebral arteries will result in incomplete perfusion of the brain if the Circle of Willis is not complete. In particular, if both posterior communicating arteries are missing, then perfusing only through the carotid arteries will result in no blood getting to parts of the brain supplied by the posterior cerebral arteries. Both posterior communicating arteries were missing in 11% of those in the 1998 study and in 14% of those in the 2002 study cited above.
Nonetheless, a 2008 study showing Circle of Willis complete in only 40% of 99 patients found no case of insufficient perfusion in functional tests of patients given unilateral cerebral perfusion. The authors concluded that “extracranial collateral circulation” provides an alternative pathway to the Circle of Willis for cerebral crossperfusion [EUROPEAN JOURNAL OF CARDIOTHORACIC SURGERY; Urbanski, PP; 33:402–408 (2008)]. Although persons with missing posterior communicating arteries could easily have pathways to opposite sides of the brain, other variants of Circle of Willis incompleteness would be expected to prevent perfusion across hemispheres.
A new system called BrainNet lets three people play a Tetris-like game using a brain-to-brain interface.
This is the first demonstration of two things: a brain-to-brain network of more than two people, and a person being able to both receive and send information to others using only their brain.
“Humans are social beings who communicate with each other to cooperate and solve problems that none of us can solve on our own,” says corresponding author Rajesh Rao, a professor in the Paul G. Allen School of Computer Science & Engineering and a co-director of the Center for Neurotechnology at the University of Washington.
‘We essentially “trick’” the neurons in the back of the brain to spread around the message that they have received signals from the eyes,’ one researcher explains.
A new study reveals surprising variations in the neural code.
University of Washington researchers created a method for two people help a third person solve a task using only their minds. Heather Wessel, a recent UW graduate with a bachelor’s degree in psychology (left), and Savannah Cassis, a UW undergraduate in psychology (right) sent information about a Tetris-like game from their brains over the internet to UW psychology graduate student Theodros Haile’s brain. Haile could then manipulate the game with his mind. Mark Stone/University of Washington.
Telepathic communication might be one step closer to reality thanks to new research from the University of Washington. A team created a method that allows three people to work together to solve a problem using only their minds.
In BrainNet, three people play a Tetris-like game using a brain-to-brain interface. This is the first demonstration of two things: a brain-to-brain network of more than two people, and a person being able to both receive and send information to others using only their brain. The team published its results April 16 in the Nature journal Scientific Reports, though this research previously attracted media attention after the researchers posted it September to the preprint site arXiv.
The most probable mainstream non-invasive way to transfer human consciousness in the intermediate future, with initial stages in the 2030s, could be the convergence of optogenetics, nanotechnologies, neuroengineering, Cloud exocortex and an array of neurotechnologies allowing to connect our wetware directly to the Cloud.
Initially, each of us will have a personal exocortex in the Cloud, the third non-biological “de-cerebral” hemisphere, which will be in constant communication with the other two biological brain hemispheres.
At some point, this “third hemisphere,” will have a threshold information content and intimate knowledge of your biology, personality and other physical world attributes in order to seamlessly integrate with your persona as a holistic entity.
Continue reading “Mind-Uploading: The Impending Meta-System Transition of Humanity” »
350 corpses stored in liquid nitrogen await immortality. But detractors say the brain’s complexity is a major stumbling block.
21st Century Medicine (21CM) is a cryobiology research company whose core mission is to develop a cryopreservation protocol sufficiently benign that whole, donated human organs could be vitrified (stored below −130 degrees Celsius without ice formation) and rewarmed when needed for transplantation –an incredibly ambitious goal that has so far eluded medical researchers. 21CM’s scientists are the original pioneers of whole organ vitrification and have been diligently working on the technique for decades. A significant milestone of their progress toward that goal is their demonstration work on rabbit kidneys. Two of their most relevant publications are “Cryopreservation of organs by vitrification: perspectives and recent advances” (Fahy, Wowk, Wu, Phan, Rasch, Chang & Zendejas 2004) and “Physical and biological aspects of renal vitrification” (Fahy, Wowk, Pagotan, Chang, Phan, Thomson & Phan 2009). These papers are a fantastic resource for anyone interested in just how difficult it is to cryopreserve large organs (and by extension whole animals) for long-term storage with the intent on later recovery of biological function. In short, it is incredibly difficult but progress is slowly being made.
The state-of-the-art whole organ vitrification techniques developed by 21CM are the basis of the human cryopreservation protocols used by some cryonics companies (e.g. Alcor). This is made clear in Alcor’s 2004 publication in the New York Academy of Sciences “The Arrest of Biological Time as a Bridge to Engineered Negligible Senescence” (Lemler, Harris, Platt & Huffman 2004).
Continue reading “21CM Cryopreservation Eval Page Foundation” »
