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But deep learning has a massive drawback: The algorithms can’t justify their answers. Often called the “black box” problem, this opacity stymies their use in high-risk situations, such as in medicine. Patients want an explanation when diagnosed with a life-changing disease. For now, deep learning-based algorithms—even if they have high diagnostic accuracy—can’t provide that information.

To open the black box, a team from the University of Texas Southwestern Medical Center tapped the human mind for inspiration. In a study in Nature Computational Science, they combined principles from the study of brain networks with a more traditional AI approach that relies on explainable building blocks.

The resulting AI acts a bit like a child. It condenses different types of information into “hubs.” Each hub is then transcribed into coding guidelines for humans to read—CliffsNotes for programmers that explain the algorithm’s conclusions about patterns it found in the data in plain English. It can also generate fully executable programming code to try out.

Scientists at Duke-NUS Medical School have identified how the first domino falls after a person encounters an allergen, such as peanuts, shellfish, pollen or dustmites. Their discovery, published in the April issue of Nature Immunology, could herald the development of drugs to prevent these severe reactions.

It is well established that when mast cells, a type of immune cell, mistake a harmless substance, such as peanuts or dust mites, as a threat, they release an immediate first wave of bioactive chemicals against the perceived threat. When mast cells, which reside under the skin, around blood vessels and in the linings of the airways and the gastrointestinal tract, simultaneously release their pre-stored load of bioactive chemicals into the blood, instant and systemic shock can result, which can be lethal without quick intervention.

More than 10 per cent of the global population suffers from food allergies, according to the World Health Organisation (WHO). As allergy rates continue to climb, so does the incidence of food-triggered anaphylaxis and asthma worldwide. In Singapore, asthma affects one in five children while food allergies are already the leading cause of anaphylactic shock.

Researchers from The University of Texas at Dallas and Seoul National University have developed an imager chip inspired by Superman’s X-ray vision that could be used in mobile devices to make it possible to detect objects inside packages or behind walls.

Chip-enabled cellphones might be used to find studs, wooden beams or wiring behind walls, cracks in pipes, or outlines of contents in envelopes and packages. The technology also could have medical applications.

The researchers first demonstrated the imaging technology in a 2022 study. Their latest paper, published in the March print edition of IEEE Transactions on Terahertz Science and Technology, shows how researchers solved one of their biggest challenges: making the technology small enough for handheld mobile devices while improving image quality.

Researchers at the Tulane University School of Medicine are working on a cost-effective, CRISPR-Cas12a-based pathogen detection tool.

Researchers from the Icahn School of Medicine at Mount Sinai have shed valuable light on the nuanced functions and intricate regulatory methods of RNA editing, a critical mechanism underlying brain development and disease.

In a study published June 26 in Nature Communications, the team reported finding major differences between postmortem and living prefrontal cortex brain tissues as they relate to one of the most abundant RNA modifications in the brain, known as adenosine-to-inosine (A-to-I) editing.

This discovery will play a significant role in shaping the development of diagnostics and therapies for brain diseases.

A UCLA Health study explored the traits of resilient individuals, discovering significant neural activities in the brain regions for cognition and emotional regulation, and healthy gut microbiome activities.

The research highlighted differences in microbiome metabolites and gene activity, indicating lower inflammation and better gut health in resilient people compared to less resilient individuals. This comprehensive approach may lead to interventions that enhance resilience to stress, possibly preventing various health issues.

Resilience and Health.

Recent research on isoporous membranes, which feature uniformly sized pores, show potential for improving the precision and efficiency of industrial separation processes by allowing solutes multiple attempts to pass through the pores.

Imagine a close basketball game that comes down to the final shot. The probability of the ball going through the hoop might be fairly low, but it would dramatically increase if the player were afforded the opportunity to shoot it over and over.

A similar idea is at play in the scientific field of membrane separations, a key process central to industries that include everything from biotechnology to petrochemicals to water treatment to food and beverage.

An international consortium has developed a new global standard for the compression and transmission of haptic information, said to be a boost for telesurgery and remote driving.

Aussie scientists have developed a new gene-editing technique that could be a major breakthrough. It could allow scientists to make accurate and more significant changes to DNA.

#Science #GeneEditing #genes