Lifeboat Foundation

The role of automatic electrocardiogram (ECG) analysis in clinical practice is limited by the accuracy of existing models. Deep Neural Networks (DNNs) are models composed of stacked transformations that learn tasks by examples. This technology has recently achieved striking success in a variety of task and there are great expectations on how it might improve clinical practice. Here we present a DNN model trained in a dataset with more than 2 million labeled exams analyzed by the Telehealth Network of Minas Gerais and collected under the scope of the CODE (Clinical Outcomes in Digital Electrocardiology) study. The DNN outperform cardiology resident medical doctors in recognizing 6 types of abnormalities in 12-lead ECG recordings, with F1 scores above 80% and specificity over 99%. These results indicate ECG analysis based on DNNs, previously studied in a single-lead setup, generalizes well to 12-lead exams, taking the technology closer to the standard clinical practice.

Amid the coronavirus pandemic that has spread across the U.S., a number of states have extended their lockdown orders in an effort to combat the spread of the virus.

As of April 8, every U.S. state has reported confirmed coronavirus cases but the stay-at-home and shelter-in-place policies all came at different times. California was the first state to issue a stay-at-home order on March 19, while South Carolina was the most recent, issuing their statewide order on April 7. Some other states like Arkansas, Iowa, North Dakota and Nebraska have yet to issue statewide stay-at-home orders.

The new viruses are not harmful to humans or closely related to SARS-CoV-2, the coronavirus that causes COVID-19.

Researchers at the Hebrew University of Jerusalem announced on Sunday that they have developed a new method of testing for COVID-19 which is not only 4–10 times faster than the tests most commonly used today, but also significantly cheaper, while supplying the same level of accuracy. Moreover, most of the materials required to perform the new test are already available in Israel, easing significantly both the country’s dire shortage of testing materials and its heavy economic dependence on foreign commercial markets. The method was developed in the labs of Prof. Nir Friedman of the Institute of Life Sciences and the School of Engineering and Computer Sciences and Dr. Naomi Haviv of Hebrew University’s Neuroscience Research Center, and is based on materials which are not affected by global shortages and can be recycled for repeated used on future tests. The method commonly used today for COVID-19 testing involves extracting RNA molecules from a patient’s sample to determine if the molecules produced have viral RNA within them, which confirms the presence of the coronavirus. The new test developed by the researchers performs the same action, but is made from more commonly attainable materials, that produce results at a much higher speed. Dr. Naomi Haviv said that “We have an efficient RNA extraction method, 4–10 times faster than the current method. It is based on magnetic beads and can be performed both robotically and manually.”

Other than the magnetic beads, all of the other materials needed to perform the tests are available for purchase in Israel. The beads themselves are recyclable and can be reused to perform future tests. “The robotic method has already undergone a series of tests at Hadassah Hospital, using hundreds of samples from patients — and is now becoming operational.”

Continue reading “Israeli researchers at Hebrew U develop faster, cheaper COVID-19 test” »

At least 70 potential coronavirus vaccines are currently in development, with 3 already in clinical trials, according to the World Health Organisation.

WHO published an updated list of vaccine efforts on April 11, showing a vast array of companies pursuing shots that could halt the coronavirus. Bloomberg News reported on the document earlier.

As the virus continues to spread, infecting more than 1.9 million people and killing more than 110,000 worldwide, researchers have been racing to develop vaccines.

According to new research in mice, aerobic exercise may actually reverse aging’s toll on essential muscle stem cells.

This is huge news… heart disease is the number one killer globally.

“They found that Myc-driven activity in heart muscle cells is critically dependent on the level of another protein called Cyclin T1, made by a gene called Ccnt1, within the cells. When the Ccnt1 and Myc genes are expressed together, the heart switches into a regenerative state and its cells start to replicate. The results are published today in the journal Nature Communications.”

Researchers trying to turn off a gene that allows cancers to spread have made a surprising U-turn. By making the gene overactive and functional in the hearts of mice, they have triggered heart cell regeneration. Since adult hearts cannot usually repair themselves once damaged, harnessing the power of this gene represents major progress towards the first curative treatment for heart disease.

Continue reading “Switching on a key cancer gene could provide first curative treatment for heart disease” »

In the midst of the coronavirus epidemic/pandemic it bears remembering the application of hyperbaric oxygen therapy to the last major pandemic that impacted the United States in 1918, the Spanish Flu Pandemic. Death was primarily by pulmonary infection and its attendant hypoxemia and respiratory failure. The first application of hyperbaric medicine to a Spanish Flu victim was likely also the first application to a human being in the United States. In 1918 Dr. Orval Cunningham of Kansas City was brought a dying friend of a fellow physician. The patient was moribund and blue. Before Cunningham could perform his planned animal experiments he was asked to treat this dying patient. With just a one-hour treatment with compressed air at 1.68 atmospheres absolute the patient experienced improvement. Combined with additional hyperbaric treatments over the next 3 days this patient’s life was saved. Others followed.

Today’s coronavirus’ mortality is due to pulmonary infection and respiratory failure. While there are differences between the Spanish Flu and coronavirus the primary pathology is in the lungs, the first organ of contact with hyperbaric therapy beyond the skin. The ability of hyperbaric oxygen to penetrate inflammatory pulmonary secretions allows adequate oxygen to reach the blood while inhibiting the inflammatory process. Applied correctly, hyperbaric therapy may have utility in coronavirus patients similar to its life-saving history with the Spanish Flu. Harch Hyperbarics Inc 504 309‑4948 www.hbot.com

Some doctors are questioning the way ventilators are being used for people with serious cases of COVID-19. Why? More data shows a high death rate for patients treated under current ventilator practices.

At the same time, these doctors are saying their patients behave more like they have high altitude sickness than a viral infection. They talk about two different types of COVID-19 patients with differing severe lung problems.

While some patients respond to treatment as expected, doctors also describe patients whose lungs seem relatively fine, but who still can’t get enough oxygen into their blood. These patients may make up the majority with severe infections.