“Our hope is that the unique mechanism of action of Opaganib, with both anti-viral and anti-inflammatory activity, will help COVID-19 patients by reducing lung inflammation, and thus preventing the disease from progressing to a stage which requires mechanical ventilation,” said Mark L. Levitt, RedHill’s medical director.
Inadequate ventilator settings may cause overwhelming inflammatory responses associated with ventilator-induced lung injury (VILI) in patients with acute respiratory distress syndrome (ARDS). Here, we examined potential benefits of glutamine (GLN) on a two-hit model for VILI after acid aspiration-induced lung injury in rats. Rats were intratracheally challenged with hydrochloric acid as a first hit to induce lung inflammation, then randomly received intravenous GLN or lactated Ringer’s solution (vehicle control) thirty min before different ventilator strategies. Rats were then randomized to receive mechanical ventilation as a second hit with a high tidal volume (TV) of 15 mL/kg and zero positive end-expiratory pressure (PEEP) or a low TV of 6 mL/kg with PEEP of 5 cm H2O. We evaluated lung oxygenation, inflammation, mechanics, and histology. After ventilator use for 4 h, high TV resulted in greater lung injury physiologic and biologic indices. Compared with vehicle treated rats, GLN administration attenuated lung injury, with improved oxygenation and static compliance, and decreased respiratory elastance, lung edema, extended lung destruction (lung injury scores and lung histology), neutrophil recruitment in the lung, and cytokine production. Thus, GLN administration improved the physiologic and biologic profiles of this experimental model of VILI based on the two-hit theory.
Keywords: acid aspiration, ARDS, glutamine, ventilator-induced lung injury.
Acute respiratory distress syndrome (ARDS) is a catastrophic syndrome among critically ill patients. One of its major causes is acid aspiration as an initial pneumonitis that may be complicated by subsequent bacterial pneumonia after inhaling low pH gastric fluid [1, 2, 3, 4]. Gastric fluid aspiration frequently occurs in trauma or critical patients with head trauma, alcohol or cerebrovascular accidents, and is also a complication of general anesthesia that occurs in 1 in 2000–3000 cases when anesthetics are used [3, 4].
Okay now I agree that Hyroxychloroquine works. Ventilators have a mortality rate of 80% yet people keep trashing this drug, while people like that French doctor say it works.
Doctors at nursing home: “It’s actually going well. People are getting better,” Armstrong told NPR, adding that after just a handful of days, some of the 39 patients on the medication are showing signs of improvement.”
“Paid Professionals:
Featured Image Source: NASA
NASA has been highly dependent on booking Russian spacecraft for almost a decade. Ever since the Space Shuttle fleet was grounded in 2011, the United States has not conducted manned flights to space. Amid the Coronavirus pandemic, a final Russian Soyuz rocket launched a NASA Astronaut for the last time to the International Space Station (ISS). On April 9, the Soyuz-2.1 rocket lifted off from the Baikonur Cosmodrome in Kazakhstan, Russia, at 4:05 a.m. Eastern time. Then the Soyuz MS-16 spacecraft was deployed into orbit about 9 minutes later. After a 6-hour trip, the spacecraft docked to the orbiting laboratory. Onboard the Soyuz spacecraft were American Astronaut Chris Cassidy, and Russian Cosmonauts Anatoly Ivanishin and Ivan Vagner. They all makeup Expedition 63, the crew will stay at the orbiting laboratory for 6 months. Due to the coronavirus, staff during the launch was limited in order to avoid spreading the COVID-19 respiratory illness. Governments from across the world have issued ‘stay at home’ orders to avoid straining healthcare systems. NASA and Roscosmos took extra precautions by limiting contact with Astronauts so they would not take any illnesses to ISS. “I knew I was going to be in quarantine these two weeks, but what’s really different is everybody else around us is in quarantine, too,” Cassidy said in a prelaunch interview on NASA TV. “It’ll be a really, really skeletal crew in the Baikonur Cosmodrome, which will be quite different.”
After the successful Soyuz launch, NASA Administrator Jim Bridenstine stated:
Medical researchers have been studying everything we know about Covid-19. What have they learned – and is it enough to halt the pandemic?
There are 70 coronavirus vaccines in development globally, with three candidates already being tested in human trials, according to the World Health Organization, as drugmakers race to find a cure for the deadly pathogen.
Here are three Black scientists and doctors making a difference during the COVID-19 pandemic.
Circa 2015
A “dialysis for cancer,” which cleanses blood of cancer, has been developed by a team of scientists from Australia.
Governments around the world are using high-tech surveillance measures to combat the coronavirus outbreak. But are they worth it?
Edward Snowden doesn’t think so.
The former CIA contractor, whose leaks exposed the scale of spying programs in the US, warns that once this tech is taken out of the box, it will be hard to put it back.
Among the drugs being investigated is remdesivir, an experimental antiviral made by the US drug company Gilead Sciences. It has been characterized as one of the most promising by health authorities, including WHO officials —though that optimism is inspired only by anecdotal information. US data on remdesivir’s performance in controlled clinical trials is expected next month, and data from late-stage trials conducted in China will be released by the end of April.
The US military, however, has already secured access to remdesivir for its service members.
On March 10, the Pentagon announced a deal with Gilead Sciences in which the pharmaceutical company would supply the military with the intravenous drug at no cost. “Together with our government and industry partners, we are progressing at almost revolutionary rates to deliver effective treatment and prevention products that will protect the citizens of the world and preserve the readiness and lethality of our service members,” Army Brig. Gen. Michael Talley, commanding general of the US Army Medical Research and Development Command (USAMRDC) and Fort Detrick, Maryland, said in a media statement at the time.
