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Researchers from Stanford University and Michigan State University have teamed up to create a nanoparticle that can eat away at the arterial plaques that lead to strokes and heart attacks in a mouse model of atherosclerosis.

The team has created a nanoparticle that acts like a Trojan horse, targeting atherosclerotic plaque to reduce its amount and prevent it from getting out of control. A considerable amount of plaque material consists of dead and dying macrophages, a type of immune cell, which have become trapped and overwhelmed while trying to remove debris and fatty deposits. As these cells die, they attract more macrophages which arrive to try to clear up the waste; they too become trapped, and this is the foundation of atherosclerotic plaque.

The new study demonstrates how the nanoparticle is able to locate the plaque while showing high selectivity for macrophages [1]. Once it has located its target, the nanoparticle enters the macrophages within the plaque and delivers a drug payload to the cells, encouraging the macrophages to engulf and consume cellular debris. Essentially, this means that the macrophages eat the dead and dying cells within the plaque and thus reduce its overall size.

LAUSANNE, Switzerland, Jan. 28, 2020 — Time is critical when diagnosing sepsis, but the tests currently used to identify this disease can take up to 72 hours. Researchers at the Laboratory of Bionanophotonic Systems (BIOS) at École Polytechnique Fédérale de Lausanne (EPFL) have developed an optical biosensor that reduces sepsis diagnosis time from several days to a few minutes. The portable biosensor is based on nanoparticle-enhanced digital plasmonic imaging.

Nanosafety researchers at the Harvard T.H. Chan School of Public Health have developed a new intervention to fight infectious disease by more effectively disinfecting the air around us, our food, our hands, and whatever else harbors the microbes that make us sick.

They used a nano-enabled platform developed at the center to create and deliver tiny, aerosolized water nonodroplets containing non-toxic, nature-inspired disinfectants wherever desired.

ACS Sustainable Chem. Eng – Inactivation of Hand Hygiene-Related Pathogens Using Engineered Water Nanostructures.

Circa 2016 could cure viruses in no time.

When you get right down to it, developing vaccines is about data and luck. Scientists start with a set of variables—what drugs a virus responds to, how effectively, and for whom—and then it’s a whole lot of trial and error until they stumble upon a cure.

One of the most exciting possibilities in medical research right now is how technology like machine learning could help researchers rapidly process those enormous sets of data, more quickly leading to cures. This is already starting to happen: In a study published Wednesday in the journal Macromolecules, researchers from IBM and Singapore’s Institute of Bioengineering and Nanotechnology reveal a breakthrough that could help prevent deadly virus infections. With the help of IBM super computer Watson, they hope their finding will soon make its way into vaccines.

Continue reading “Here’s how artificial intelligence could cure disease in the future” »

Michigan State University and Stanford University scientists have invented a nanoparticle that eats away—from the inside out—portions of plaques that cause heart attacks.

Bryan Smith, associate professor of biomedical engineering at MSU, and a team of scientists created a “Trojan Horse” nanoparticle that can be directed to eat debris, reducing and stabilizing plaque. The discovery could be a potential treatment for atherosclerosis, a leading cause of death in the United States.

The results, published in the current issue of Nature Nanotechnology, showcases the nanoparticle that homes in on atherosclerotic plaque due to its high selectivity to a particular immune cell type—monocytes and macrophages. Once inside the macrophages in those plaques, it delivers a drug agent that stimulates the cell to engulf and eat cellular debris. Basically, it removes the diseased/dead cells in the plaque core. By reinvigorating the macrophages, plaque size is reduced and stabilized.

New technique could be used to design a wide range of optical devices.

We’re still a long way from Star Trek-style tricorders that can instantly diagnose disease, but medical startup Nanox is hoping to bring a little of the 24th century to a hospital near you. The company has unveiled a new low-cost X-ray scanner called the Nanox. Arc. It hopes to deploy 15,000 units in the coming years, with the aim of making medical scans more available and affordable.

Nanox was founded in 2016 by Japanese venture capitalist Hitoshi Masuya in partnership with Sony. The consumer electronics giant later bowed out, but Masuya joined forces with current CEO Ran Poliakine to split the company’s operations between Israel and Japan. Nanox has now raised a total of $55 million to fund the development of Nanox. Arc, which supposedly offers the same capabilities of traditional X-ray machines with a much smaller footprint and lower operating costs.

Current X-ray machinery is bulky, requiring arrays of rotating tubes with superheated filaments that produce electron clouds. When moved near a metal anode, the filament produces the X-rays needed for imaging. These giant analog contraptions require heavy shielding to keep patients safe, and they use a lot of power. There’s also a substantial upfront cost that can run $2–3 million. The Nanox. Arc, on the other hand, uses silicon micro-electromechanical systems (MEMs) in the form of more than 100 million molybdenum nano-cones that generate electrons.

A dumbbell-shaped nanoparticle powered just by the force and torque of light has become the world’s fastest-spinning object.

Scientists at Purdue University created the object, which revolves at 300 billion revolutions per minute. Or, put another way, half a million times faster than a dentist’s drill.

In addition, the silica nanoparticle can serve as the world’s most sensitive torque detector, which researchers hope will be used to measure the friction created by quantum effects.

#biophotonics #photonics

ONNA, Japan, Jan. 13, 2020 — Scientists at the Okinawa Institute of Science and Technology (OIST) Graduate University have developed a light-based device that can act as a biosensor, detecting biological substances in materials, such as harmful pathogens in food. The scientists said that their tool, an optical microresonator, is 280× more sensitive than current industry-standard biosensors, which can detect only cumulative effects of groups of particles, not individual molecules.