A new study suggests that a bodybuilding supplement may help protect against cognitive decline by reducing amyloid plaque buildup, at least in mice.
HBP researchers from Germany performed detailed cytoarchitectonic mapping of distinct areas in a human cortical region called frontal operculum and, using connectivity modelling, linked the areas to a variety of different functions including sexual sensation, muscle coordination as well as music and language processing.
The study contributes to the further unravelling of the relationship of the human brain’s structure with function, and is the first proof-of-concept of structural and functional connectivity analysis of the frontal operculum. The newly identified cytoarchitectonic areas have been made publicly available as part of the Julich-Brain Atlas on the EBRAINS platform, inviting for future research to further characterise this brain region.
Based on cell-body stained histological sections in ten postmortem brains (five females and five males), HBP researchers from Heinrich Heine University Düsseldorf and Research Centre Jülich identified three new areas in the frontal operculum: Op5, Op6 and Op7. Each of these areas had a distinct cytoarchitecture. Connectivity modelling showed that each area could be ascribed a distinct functional role.
Immune system changes in the pregnant body that protect the fetus appear to extend to the brain, where a decrease in immune cells late in gestation may factor into the onset of maternal behavior, new research in rats suggests.
In adult female rats that had never given birth—which typically don’t like being around babies—depletion of these cells sped up their care for rat newborns that were placed in their cage.
The loss of these cells, called microglia, and the related uptick in motherly attentiveness were also associated with changes to neuron activity in several regions of the rat brain, suggesting shifts in immune function have a role in regulating maternal behavior.
For many people, they are tiny pests. These fruit flies that sometimes hover over a bowl of peaches or a bunch of bananas. But for a dedicated community of researchers, fruit flies are an excellent model organism and source of information into how neurons self-organize during the insect’s early development and form a complex, fully functioning nervous system.
That’s the scientific story on display in this beautiful image of a larval fruit fly’s developing nervous system. Its subtext is: fundamental discoveries in the fruit fly, known in textbooks as Drosophila melanogaster, provide basic clues into the development and repair of the human nervous system. That’s because humans and fruit flies, though very distantly related through the millennia, still share many genes involved in their growth and development. In fact, 60 percent of the Drosophila genome is identical to ours.
Once hatched, as shown in this image, a larval fly uses neurons (magenta) to sense its environment. These include neurons that sense the way its body presses against the surrounding terrain, as needed to coordinate the movements of its segmented body parts and crawl in all directions.
David Chalmers is a philosopher at New York University and the Australian National University. He is Professor of Philosophy and co-director of the Center for Mind, Brain, and Consciousness at NYU, and also Professor of Philosophy at ANU.
Chalmers works in the philosophy of mind and in related areas of philosophy and cognitive science. He is especially interested in consciousness, but am also interested in all sorts of other issues in the philosophy of mind and language, metaphysics and epistemology, and the foundations of cognitive science.
From an early age, he excelled at mathematics, eventually completing his undergraduate education at the University of Adelaide with a Bachelor’s degree in Mathematics and Computer Science. He then briefly studied at Lincoln College at the University of Oxford as a Rhodes Scholar before receiving his PhD at Indiana University Bloomington under Douglas Hofstadter. He was a Postdoctoral Fellow in the Philosophy-Neuroscience-Psychology program directed by Andy Clark at Washington University in St. Louis from 1993 to 1995, and his first professorship was at UC Santa Cruz, from August 1995 to December 1998.
The Klotho gene has gained increasing attention for its anti-aging properties. In the most recent installment of this series, we explored the promising cognitive benefits of administering Klotho to both mice and monkeys, the results from which may be mirrored in humans. The benefits of this circulating hormone, however, extend beyond the brain.
Klotho was first discovered as the antiaging gene in 1997 when researchers found that enhancing its expression could increase the lifespan of mice by more than 30%. Although a variety of different genes and environmental factors can influence longevity, studies have shown that Klotho-deficient mice not only have shorter lifespans but also experience more age-related complications. Premature aging in these mice often was accompanied by loss of muscle and fat tissue, thinning skin, reduced fertility, cardiovascular complications, movement abnormalities, and bone disease. Since Klotho is primarily produced in the kidneys, it is not surprising that many of these age-related complications often result from kidney dysfunction.
The kidneys generate two types of Klotho: a transmembrane protein that inserts itself into the cell membrane and mediates kidney function, and a secreted hormone that is released into the bloodstream. Individuals with naturally high levels of the hormone in their blood seem to not only live longer and be more resistant to age-related complications but also perform better on learning and memory tasks. In fact, even when a relatively small dose of Klotho is administered, animal studies have shown that the brain undergoes significant changes that allow more connections to be made in the hippocampus, the brain’s learning and memory center.
Are quantum events required for consciousness in a very special sense, far beyond the general sense that quantum events are part of all physical systems? What would it take for quantum events, on such a micro-scale, to be relevant for brain function, which operates at the much higher level of neurons and brain circuits? What would it mean?
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The Australian military is funding a project to grow intelligent “mini-brains” in petri dishes. The goal is to use these “DishBrains” to design better AIs — and, eventually, even combine the two, creating AIs merged with processing features of human brain cells.
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DEAR MAYO CLINIC: I’ve heard about several people who have experienced sudden cardiac arrest. What is cardiac arrest? And how is it different from a heart attack? What do you do for someone who has this condition?
ANSWER: Cardiac arrest, or sudden cardiac arrest as it is more formally known, is a medical emergency. Think of it as a problem with the heart’s electrical activity. This synchronized electrical activity allows the heart to fill and pump blood normally. Sudden cardiac arrest can happen unexpectedly and quickly, and the heart stops working. It’s not the same as a heart attack, but it is just as critical that treatment occurs rapidly.
Cardiac arrest is when the heart cannot fulfill its duties, such as pumping oxygenated blood around the body to reach critical areas such as the brain and the rest of the body. It is sometimes called “sudden” because it seems to happen without warning. A person suddenly loses all heart activity, stops breathing and becomes unconscious. Without immediate treatment, sudden cardiac arrest can lead to death.
