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Suvorexant (Belsomra), a dual orexin receptor antagonist approved for insomnia, reduced levels of tau phosphorylation and amyloid beta, a small clinical trialopens in a new tab or window showed.

The ratio of phosphorylated tau-threonine-181 (p-tau-181) to unphosphorylated tau-threonine-181 decreased 10% to 15% in cognitively normal adults treated with suvorexant 20 mg compared with placebo, reported Brendan Lucey, MD, MSCI, of Washington University School of Medicine in St. Louis, and co-authors.

Amyloid-beta levels fell 10% to 20% compared with placebo starting 5 hours after suvorexant administration, the researchers wrote in Annals of Neurologyopens in a new tab or window.

Continue reading “Alzheimer’s Proteins Reduced by Sleep Drug” »

The researchers found those who showed positive age beliefs were 30% more likely to recover from cognitive impairment than those who held negative age beliefs, irrespective of the severity of the cognitive decline. The time for recovery was also quicker in people with positive age beliefs.

They also found that the participants who stayed positive about aging were less likely to develop mild cognitive impairment over 12 years.

It is widely believed that memory loss associated with aging is irreversible. However, a new study says people who embrace aging positively may recover from cognitive decline.

Continue reading “Study Says Staying Positive About Aging May Help Reverse Cognitive Decline” »

This new “nano-excitonic transistor” could revolutionize data processing, especially in the age of AI.

There are approximately 30 trillion cells in a human body and our health is predicated on them properly interacting with and supporting each other, with the immune system playing a particularly pivotal role. One of the defining characteristics of aging is a decline in the proper functioning of our immune system. Centenarians, a rare population of individuals who reach 100 years or more, experience delays in aging-related diseases and mortality which suggests their immune systems remain functional into extreme old age.

Led by researchers from Boston University Chobanian & Avedisian School of Medicine and Tufts Medical Center, a new study finds centenarians harbor distinct immune cell type composition and activity and possess highly functional immune systems that have successfully adapted to a history of sickness allowing for exceptional longevity. These immune cells may help identify important mechanisms to recover from disease and promote longevity.

“Our data support the hypothesis that centenarians have protective factors that enable to recover from disease and reach extreme old ages,” said lead author Tanya Karagiannis, Ph.D., senior bioinformatician, Center for Quantitative Methods and Data Science, Institute for Clinical Research and Health Policy Studies at Tufts Medical Center.

A new study of 30 million people found that even small amounts of exercise could lower risk for heart disease, certain cancers and early death.

As chatbot responses begin to proliferate throughout the Internet, they will, in turn, impact future machine learning algorithms that mine the Internet for information, thus perpetuating and amplifying the impact of the current programming biases evident in ChatGPT.

ChatGPT is admittedly a work in progress, but how the issues of censorship and offense ultimately play out will be important. The last thing anyone should want in the future is a medical diagnostic chatbot that refrains from providing a true diagnosis that may cause pain or anxiety to the receiver. Providing information guaranteed not to disturb is a sure way to squash knowledge and progress. It is also a clear example of the fallacy of attempting to input “universal human values” into AI systems, because one can bet that the choice of which values to input will be subjective.

If the future of AI follows the current trend apparent in ChatGPT, a more dangerous, dystopic machine-based future might not be the one portrayed in the Terminator films but, rather, a future populated by AI versions of Fahrenheit 451 firemen.

Want to send your faraway lover a kiss? A Chinese contraption with warm, moving silicon “lips” appears to have just the answer.

The device, advertised as a way to let long-distance couples share “real” physical intimacy, is causing a buzz among Chinese social media users, who have reacted with both intrigue and shock.

Equipped with pressure sensors and actuators, the device is said to be able to mimic a real kiss by replicating the pressure, movement and temperature of a user’s lips.

The James Webb Space Telescope found six massive galaxies that some scientists never thought could exist. The telescope is so powerful it might have just shattered scientific understanding of the universe. Theoretical Physicist and best selling author Dr. Michio Kaku talked to Gadi Schwartz about the groundbreaking report.

A team of scientists has proposed that we could use existing Earth-based observatories to hunt for highly intelligent alien life forms and their advanced warp drive technologies.