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Search results for 'Nicholi': Page 8

Dec 31, 2022

New research reveals how the brain holds information in mind

Posted by in categories: biological, computing, neuroscience

MIT neuroscientists have published a key new insight on how working memory functions, in a study published in PLOS Computational Biology.

The researchers at The Picower Institute for Learning and Memory compared measurements of brain cell activity in an animal performing a working memory task with the output of various computer models representing two theories on the underlying mechanism for holding information in mind.

The results favored the newer theory that a network of neurons stores information by making short-lived changes in the connections, or synapses, between them, rather than the traditional theory that memory is maintained by neurons remaining persistently active.

Dec 29, 2022

Study sheds light on why human lymph nodes lose their function with age

Posted by in categories: biotech/medical, life extension

//Although lipomatosis is very common and increases with age, scientists have previously devoted little discussion and research to it. Scientists at Uppsala University have just published a study that offers significant insights into the causes of human lymph node function decline with aging and the effects on immune system performance.

Scientists carefully examined more than 200 lymph nodes to show that lipomatosis starts in the medulla, which is the center of the lymph node. They also provided evidence connecting lipomatosis to converting lymph node supporting cells (fibroblasts) into adipocytes (fat cells). They also demonstrate that fibroblast subtypes in the medulla are more likely to develop into adipocytes.\.


The study is a first step toward understanding why lipomatosis occur.

Dec 25, 2022

This is your brain. This is your brain on code

Posted by in category: robotics/AI

๐“๐ก๐ข๐ฌ ๐ข๐ฌ ๐ฒ๐จ๐ฎ๐ซ ๐›๐ซ๐š๐ข๐ง ๐จ๐ง ๐œ๐จ๐๐ž

๐™ˆ๐™„๐™ ๐™ง๐™š๐™จ๐™š๐™–๐™ง๐™˜๐™๐™š๐™ง๐™จ ๐™–๐™ง๐™š ๐™™๐™ž๐™จ๐™˜๐™ค๐™ซ๐™š๐™ง๐™ž๐™ฃ๐™œ ๐™ฌ๐™๐™ž๐™˜๐™ ๐™ฅ๐™–๐™ง๐™ฉ๐™จ ๐™ค๐™› ๐™ฉ๐™๐™š ๐™—๐™ง๐™–๐™ž๐™ฃ ๐™–๐™ง๐™š ๐™š๐™ฃ๐™œ๐™–๐™œ๐™š๐™™ ๐™ฌ๐™๐™š๐™ฃ ๐™– ๐™ฅ๐™š๐™ง๐™จ๐™ค๐™ฃ ๐™š๐™ซ๐™–๐™ก๐™ช๐™–๐™ฉ๐™š๐™จ ๐™– ๐™˜๐™ค๐™ข๐™ฅ๐™ช๐™ฉ๐™š๐™ง ๐™ฅ๐™ง๐™ค๐™œ๐™ง๐™–๐™ข


Researchers from MITโ€™s Computer Science and Artificial Intelligence Laboratory (CSAIL) found that the Multiple Demand and Language brain systems encode specific code properties and uniquely align with machine-learned representations of code.

Dec 24, 2022

Massive tentacled microbe may be direct ancestor of all complex life

Posted by in category: biological

Scientists successfully grew Asgard archaea in the lab and took detailed images.

Dec 23, 2022

Research shows fatty liver disease endangers brain health

Posted by in categories: biotech/medical, health, neuroscience

In a study examining the link between non-alcoholic fatty liver disease (NAFLD) and brain dysfunction, scientists at the Roger Williams Institute of Hepatology, affiliated to Kingโ€™s College London and the University of Lausanne, found an accumulation of fat in the liver causes a decrease in oxygen to the brain and inflammation to brain tissueโ€”both of which have been proven to lead to the onset of severe brain diseases.

The paper appears in the Journal of Hepatology.

NAFLD affects approximately 25% of the population and more than 80% of morbidly obese people. Several studies have reported the negative effects of an unhealthy diet and obesity can have on however this is believed to be the first study that clearly links NAFLD with deterioration and identifies a potential therapeutic target.

Dec 22, 2022

The Disturbing Reality of Cobalt Mining for Rechargeable Batteries

Posted by in categories: sustainability, transportation

The truth about Cobalt. The demand for colbalt is on the rise as we transition to electric vehicles is at an all time high.


Taken from JRE #1914 w/Siddharth Kara:

Continue reading “The Disturbing Reality of Cobalt Mining for Rechargeable Batteries” »

Dec 22, 2022

Big dynorphin may protect neurons from the accumulation of Alzheimerโ€™s-associated amyloid

Posted by in categories: biotech/medical, computing, neuroscience

๐€๐ฅ๐ณ๐ก๐ž๐ข๐ฆ๐ž๐ซโ€™๐ฌ ๐ƒ๐ข๐ฌ๐ž๐š๐ฌ๐ž


One of the main features of Alzheimerโ€™s disease is that the ฮฒ-amyloid peptide, a molecule found inside neurons that has many diverse functions, begins to fold incorrectly and accumulates. This process, which ends up causing neuronal death, is linked to a series of other cellular alterations, making it difficult to determine whether they are the cause or the consequence. An example is the case of the deregulation of a type of dynorphin.

Dynorphins are the bodyโ€™s own opioid peptides, which play a key role in many brain pathways. They are located in different areas of the brain, such as the hippocampus, amygdala or hypothalamus, and are involved in memory processes, emotion control, stress and pain, and among other processes. In addition, several studies have shown their involvement in epilepsy, stroke, addictions, depression and schizophrenia.

Continue reading “Big dynorphin may protect neurons from the accumulation of Alzheimerโ€™s-associated amyloid” »

Dec 21, 2022

Study unveils neural pathway promoting regeneration after traumatic injuries

Posted by in category: neuroscience

๐’๐ญ๐ฎ๐๐ฒ ๐ฎ๐ง๐ฏ๐ž๐ข๐ฅ๐ฌ ๐ง๐ž๐ฎ๐ซ๐š๐ฅ ๐ฉ๐š๐ญ๐ก๐ฐ๐š๐ฒ ๐ฉ๐ซ๐จ๐ฆ๐จ๐ญ๐ข๐ง๐  ๐ซ๐ž๐ ๐ž๐ง๐ž๐ซ๐š๐ญ๐ข๐จ๐ง ๐š๐Ÿ๐ญ๐ž๐ซ ๐ญ๐ซ๐š๐ฎ๐ฆ๐š๐ญ๐ข๐œ ๐ข๐ง๐ฃ๐ฎ๐ซ๐ข๐ž๐ฌ

๐™Ž๐™ฉ๐™ช๐™™๐™ž๐™š๐™จ ๐™š๐™ญ๐™ฅ๐™ก๐™ค๐™ง๐™ž๐™ฃ๐™œ ๐™ฉ๐™๐™š ๐™ฃ๐™š๐™ช๐™ง๐™–๐™ก ๐™ฅ๐™ง๐™ค๐™˜๐™š๐™จ๐™จ๐™š๐™จ ๐™ž๐™ฃ๐™ซ๐™ค๐™ก๐™ซ๐™š๐™™ ๐™ž๐™ฃ ๐™˜๐™š๐™ก๐™ก ๐™ง๐™š๐™œ๐™š๐™ฃ๐™š๐™ง๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™–๐™ง๐™š ๐™ค๐™› ๐™˜๐™ง๐™ช๐™˜๐™ž๐™–๐™ก ๐™ž๐™ข๐™ฅ๐™ค๐™ง๐™ฉ๐™–๐™ฃ๐™˜๐™š, ๐™–๐™จ ๐™ฉ๐™๐™š๐™ฎ ๐™˜๐™ค๐™ช๐™ก๐™™ ๐™ฅ๐™–๐™ซ๐™š ๐™ฉ๐™๐™š ๐™ฌ๐™–๐™ฎ ๐™ฉ๐™ค๐™ฌ๐™–๐™ง๐™™๐™จ ๐™ฉ๐™๐™š ๐™™๐™š๐™ซ๐™š๐™ก๐™ค๐™ฅ๐™ข๐™š๐™ฃ๐™ฉ ๐™ค๐™› ๐™ข๐™ค๐™ง๐™š ๐™š๐™›๐™›๐™š๐™˜๐™ฉ๐™ž๐™ซ๐™š ๐™ฉ๐™ง๐™š๐™–๐™ฉ๐™ข๐™š๐™ฃ๐™ฉ๐™จ ๐™›๐™ค๐™ง ๐™ข๐™–๐™ฃ๐™ฎ ๐™ฅ๐™–๐™ฉ๐™๐™ค๐™ก๐™ค๐™œ๐™ž๐™š๐™จ ๐™–๐™จ๐™จ๐™ค๐™˜๐™ž๐™–๐™ฉ๐™š๐™™ ๐™ฌ๐™ž๐™ฉ๐™ ๐™ฉ๐™๐™š ๐™ข๐™ช๐™ฉ๐™–๐™ฉ๐™ž๐™ค๐™ฃ๐™จ ๐™ค๐™ง ๐™™๐™š๐™ฉ๐™š๐™ง๐™ž๐™ค๐™ง๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™ค๐™› ๐™˜๐™š๐™ก๐™ก๐™จ. ๐™ˆ๐™ž๐™˜๐™ง๐™ค๐™œ๐™ก๐™ž๐™–, ๐™ฉ๐™๐™š ๐™—๐™ง๐™–๐™ž๐™ฃโ€™๐™จ ๐™ง๐™š๐™จ๐™ž๐™™๐™š๐™ฃ๐™ฉ ๐™ž๐™ข๐™ข๐™ช๐™ฃ๐™š ๐™˜๐™š๐™ก๐™ก๐™จ, ๐™—๐™š๐™˜๐™ค๐™ข๐™š ๐™–๐™˜๐™ฉ๐™ž๐™ซ๐™š ๐™ž๐™ฃ ๐™ง๐™š๐™จ๐™ฅ๐™ค๐™ฃ๐™จ๐™š ๐™ฉ๐™ค ๐™ฅ๐™–๐™ฉ๐™๐™ค๐™ก๐™ค๐™œ๐™ž๐™š๐™จ, ๐™จ๐™ค๐™ข๐™š๐™ฉ๐™ž๐™ข๐™š๐™จ ๐™ก๐™š๐™–๐™™๐™ž๐™ฃ๐™œ ๐™ฉ๐™ค ๐™˜๐™๐™ง๐™ค๐™ฃ๐™ž๐™˜ ๐™ž๐™ฃ๐™›๐™ก๐™–๐™ข๐™ข๐™–๐™ฉ๐™ž๐™ค๐™ฃ ๐™–๐™ฃ๐™™ ๐™ฉ๐™๐™š ๐™จ๐™˜๐™–๐™ง๐™ง๐™ž๐™ฃ๐™œ ๐™ค๐™› ๐™ฉ๐™ž๐™จ๐™จ๐™ช๐™š.


Studies exploring the neural processes involved in cell regeneration are of crucial importance, as they could pave the way towards the development of more effective treatments for many pathologies associated with the mutations or deterioration of cells. Microglia, the brainโ€™s resident immune cells, become active in response to pathologies, sometimes leading to chronic inflammation and the scarring of tissue.

Continue reading “Study unveils neural pathway promoting regeneration after traumatic injuries” »

Dec 20, 2022

Our Protective Outer Layer

Posted by in categories: biotech/medical, life extension

Throughout our lives, our skin goes through a lot. We get sunburns, we skin our knees, we bleed, we scar and we do it again. Our skin is our largest organ and, in many ways, serves as our protector. Beyond acting as a protective barrier between us and our environment, our skin regulates our body temperature, provides immune protection against harmful microbes and blocks out harmful sunlight in ways that benefit the whole body. And when skin is injured, blood brings healing substances to the site to promote healing as the body awaits new, replacement skin cells.

Regardless of scrapes and scratches, skin cells are constantly renewing themselves throughout our lives โ€” a process reliant on skin stem cells. These skin stem cells turn over slowly, keeping our skin healthy and young. But as we age, these skin stem cells either numerically or functionally deplete, our skin thins and we are consequentially at higher risk for developing ulcers. The older the skin, the harder it is to heal these ulcers, meaning they can become chronic, open wounds that impact lifestyle and invite infection.

But what if we could activate a skin stem cell to be more responsive to injury? To get an 80-year-oldโ€™s skin to function like a 30-year-oldโ€™s skin? Could we reverse skin stem cell age-related deterioration and improve their turnover? What if we could do so in a way that healed wounds regeneratively, without any scarring? With these questions in mind, a collaborative team of researchers from the Mass General Brigham, Boston Childrenโ€™s Hospital, and four additional Harvard institutions set off to study these powerful cells.

Dec 19, 2022

Life-changing: New gene therapy gel heals decades-old wounds from skin disease

Posted by in category: biotech/medical

A gene therapy gel for a blistering skin disease developed at Stanford Medicine has worked wonders in a double-blind, placebo-controlled clinical trial.

The gel, called B-VEC, was intended to treat dystrophic epidermolysis bullosa, a skin disease that results in large open wounds that last for decades. The condition is extremely painful, and the medical treatment is mostly limited to palliative care.

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