Lifeboat Foundation

After decades of research, here it is: the first promising evidence in humans, albeit imperfect and early, that a cocktail of three drugs is enough to reverse the epigenetic clock—a measure of someone’s biological age and health.

The results came as a surprise to even the research team, who originally designed the trial for something a little less dazzling: to look at human growth hormone’s effects on the thymus, the cradle of the body’s immune system that deteriorates with age.

“Maintained immune function is seen in centenarians,” and thymus function is linked to all-cause mortality, explained study author Dr. Gregory Fahy at Intervene Immune, based in Los Angeles, California. “So we were hoping to use a year of growth hormone to maintain thymus function in middle-aged men, right before the tissue’s functions take a nosedive,” he said.

For the December edition of the Journal Club hosted by Dr. Oliver Medvedik, we are joined by Dr. Matthew O’ Connor (Oki) formerly of SENS Research Foundation and now the head researcher at Underdog Pharma, a spin-off biotech company that is developing research conducted at SENS into a hopefully viable solution for heart disease.

Dr. O’Connor will be giving a short presentation covering the story of 7-Ketocholesterol, a harmful byproduct of oxidized cholesterol that Underdog believes is a suitable target for therapeautic intervention to prevent the formation of artery plaques, the basis of atherosclerosis. Then, we will review the new paper that his team has published and follow it up with discussion and questions.

Yes, the simple act of juggling has recently been linked with better brain function. A new study reveals that learning to juggle may cause certain areas of your brain to grow.

The study found that volunteers who participated in a juggling exercise improved white matter in two areas of their brains involved in visual and motor activity.

‘We have demonstrated that there are changes in the white matter of the brain — the bundles of nerve fibres that connect different parts of the brain — as a result of learning an entirely new skill,’ explains Dr Heidi Johansen-Berg of the Department of Clinical Neurology, University of Oxford, who led the work.

For many years, chili has been hailed for its therapeutic properties, and now researchers have found that eating chili peppers regularly can cut the risk of death from heart disease and stroke.

Carried out in Italy, where chili is a common ingredient, the study compared the risk of death among 23,000 people, some of whom ate chili and some of whom didn’t.

An organized tide of brain waves, blood and spinal fluid pulsing through a sleeping brain may flush away neural toxins that cause Alzheimer’s and other diseases.

A small study reveals that rapamycin, a drug with a long history as an immune suppressor, can improve tone and reduce wrinkles and sagging in human skin.

CRISPR provides window into axolotl limb replacement.

With collagen supplements you can regrow cartilage pretty easily. Most supplements work better than medicine when it comes to tissue repair.

Humans have the ability to regrow cartilage, a new study has found.

In a way similar to how salamanders and other creatures can regrow lost limbs, humans have the capacity to repair and regenerate cartilage in their joints, researchers at Duke Health discovered.

Continue reading “Humans’ ‘inner salamander’ capacity could regrow cartilage” »

Trials of the gene editor in people began in the United States this year, a first step toward fulfilling the technology’s medical promise.