Lifeboat Foundation

(Medical Xpress)—A team of researchers affiliated with several institutions in Japan has succeeded in growing kidneys from stem cells that worked as they were supposed to after being transplanted into rats and pigs. The team outlines their work and results in a paper they have had published in Proceedings of the National Academy of Sciences.

Researchers have met with success in the past, using human stem cells to grow organs, in this case kidneys, unfortunately, the kidneys that have been grown have all developed without a urinary pathway—the means by which urine makes its way out of the kidney and to a tube that connects with the bladder. Such kidneys experience hydronephrosis, where they bloat with urine. In this new effort, the researchers found a way to grow both a kidney and a pathway and an initial bladder, all of which successfully replicated the work normally done by natural organs for a period of time.

The team used the organogenic niche method to grow kidneys using rat stem cells, which when tested, were able to produce urine. Next, they grew a urinary pathway, which was in effect, a type of drainage tube. Then, they grew a blabber that would be compatible with the drainage tube. With all the parts, grown, the kidney was placed inside a rat, then the pathway was added, followed by the bladder they’d grown—the new bladder was then connected to the rat’s native bladder. After sewing up the rat, they found the whole system worked. The team then repeated what they had done with a much larger animal, one much closer in size to humans—a pig—and found the same results.

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This week’s episode welcomes Bill Andrew’s, Ph. D., President and Founder of the biotechnology firm Sierra Sciences. Bill is widely considered the foremost researcher on aging and telomeres and most of his entire professional career has been devoted to finding a cure for aging. Most notably, he led a team in 1997 at Geron Corporation to successfully identify the human enzyme telomerase. An enzyme that causes Telomeres to lengthen, thus enabling cells to replicate itself without hitting their Hayflick limit (i.e. the number of times a cell is able to reproduce itself). It is believed that only human embryonic stem cells and cancer cells are immortal and do not possess a Hayflick limit.

Our conversation explores the science, possibilities, and social impacts of finding a cure for aging. He explains his company’s quest to create a safe and affordable drug that will lengthen telomeres in every cell in your body. He believes his research team is one year away from starting human trials if he receives the additional funding necessary to finish his research.

Join us in this fascinating discussion that is sure to change the way you view aging and our future.

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A team from the Francis Crick Institute wants a permit to use so-called CRISPR/Cas 9 technology in basic research.

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Just days ago it was announced that a 3D printed guide developed by researchers in Minnesota could help facilitate the regrowth of damaged nerves within the human body. In the wake of this exciting breakthrough, is another progressive use for 3D printing within the medical world, as the same researchers have found a way to release biomolecules into the body through a 3D printed scaffold with more precision than ever before.

Continue reading “3D printed scaffolds allow for precise release of biomolecules into the human body” »

Having significantly damaged nerve tissue is bad for a lot of reasons because it doesn’t regenerate easily and it can lead to various serious medical conditions including paralysis. But many scientists are already studying ways of fixing this issue, and a team of researchers from the University of Minnesota, Virginia Tech, University of Maryland, Princeton University, and Johns Hopkins University has figured out how to use 3D printing for nerve growth.

DON’T MISS: 85 legitimate iPhone apps that were infected with malware in the big App Store hack

Continue reading “Breakthrough medical discovery: 3D printing might be used to regenerate nerves” »

Researchers from the Institute of General Physics of the Russian Academy of Sciences, the Institute of Bioorganic Chemistry of the Russian Academy of Sciences and MIPT have made an important step towards creating medical nanorobots. They discovered a way of enabling nano- and microparticles to produce logical calculations using a variety of biochemical reactions.

Details of their research project are given in the journal Nature Nanotechnology. It is the first experimental publication by an exclusively Russian team in one of the most cited scientific magazines in many years.

The paper draws on the idea of computing using biomolecules. In electronic circuits, for instance, logical connectives use current or voltage (if there is voltage, the result is 1, if there is none, it’s 0). In biochemical systems, the result can a given substance.

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A sequel to Steven Spielberg’s epic movie, MINORITY REPORT is set in Washington, D.C., 10 years after the demise of Precrime, a law enforcement agency tasked with identifying and eliminating criminals … before their crimes were committed. Now, in 2065, crime-solving is different, and justice leans more on sophisticated and trusted technology than on the instincts of the precogs. Sept. 21 series premiere Mondays 9/8:00c

LIMITLESS, based on the feature film, is a fast-paced drama about Brian Finch, who discovers the brain-boosting power of the mysterious drug NZT and is coerced by the FBI into using his extraordinary cognitive abilities to solve complex cases for them. Sept. 22 series premiere Tuesdays 10/9c

Topics: Cognitive Science/Neuroscience | Entertainment/New Media | Human Enhancement | VR/Augmented Reality/Computer Graphics.

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Human embryos are at the center of a debate over the ethics of gene editing (credit: Dr. Yorgos Nikas/SPL)

The first application to pursue CRISPR/Cas9 genome-editing research in viable human embryos has been submitted to the UK’s fertility regulator by a team of researchers affiliated with the Francis Crick Institute in London.

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Imagine a “smart pill” that can sense problems in your intestines and actively release the appropriate drugs. We have the biological understanding to create such a device, but we’re still searching for electronic materials (like batteries and circuits) that pose no risk if they get stuck in our bodies. In Trends in Biotechnology on September 21, Christopher Bettinger of Carnegie Mellon University presents a vision for creating safe, consumable electronics, such as those powered by the charged ions within our digestive tracts.

Edible electronic medical devices are not a new idea. Since the 1970s, researchers have been asking people to swallow prototypes that measure temperature and other biomarkers. Currently, there are ingestible cameras for gastrointestinal surgeries as well as sensors attached to medications used to study how drugs are broken down in the body.

“The primary risk is the intrinsic toxicity of these materials, for example, if the battery gets mechanically lodged in the gastrointestinal tract–but that’s a known risk. In fact, there is very little unknown risk in these kinds of devices,” says Bettinger, a professor in materials science and engineering. “The breakfast you ate this morning is only in your GI tract for about 20 hours–all you need is a battery that can do its job for 20 hours and then, if anything happens, it can just degrade away.”

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