Lifeboat Foundation

Can therapy rewire the brain? For individuals struggling with both depression and obesity, a new Stanford Medicine study says yes—when the therapy is the right fit. Researchers found that cognitive behavioral therapy focused on problem-solving reduced depression symptoms in a third of participants and altered their brain activity in ways that could predict longer-term benefits. The findings have been published in Science Translational Medicine.

Depression affects millions of people worldwide and becomes particularly challenging to treat when paired with obesity, a condition that complicates recovery and worsens outcomes. Previous research has suggested that brain regions associated with cognitive control—areas responsible for regulating emotions and behaviors—might influence how individuals respond to therapy.

This study aimed to determine whether a therapy specifically designed to engage these brain circuits could lead to sustained improvements in depression symptoms, particularly in individuals with comorbid depression and obesity. The researchers also investigated whether early changes in brain activity could predict long-term therapeutic success, paving the way for more personalized treatment strategies.

Basically bio electricity once controlled could offer eternal life for humans because we could simply use the electricity to have longer if not indefinite lifespans that don’t require as much food for energy.

In the near future, birth defects, traumatic injuries, limb loss and perhaps even cancer could be cured through bioelectricity—electrical signals that communicate to our cells how to rebuild themselves. This innovative idea has been tested on flatworms and frogs by biologist Michael Levin, whose research investigates how bioelectricity provides the blueprint for how our bodies are built—and how it could be the future of regenerative medicine.

Levin is a professor of biology at Tufts University and director of the Tufts Center for Regenerative and Developmental Biology.

It’s been more than three decades, but still there are only two treatments for a stroke: either rapid use of a clot-busting medication called tPA or surgical removal of a clot from the brain with mechanical thrombectomy. However, only 5% to 13% percent of stroke cases are actually eligible for these interventions.

“We need to be persistent with our research to find a new therapy for stroke,” says Rajkumar Verma, M.Pharm., Ph.D., assistant professor, Department of Neuroscience at UConn School of Medicine working in cross-campus collaboration with Professor Raman Bahal Ph.D. of the Department of Pharmaceutical Sciences in the UConn School of Pharmacy. “Stroke research is hard and challenging to do. But without trying we won’t make progress. We need to keep trying. UConn is determined to keep trying.”

In addition to being life-threatening, stroke is the major cause of long-term disability worldwide.

Illinois researchers have found an unbelievable link between infection with Covid and cancer regression where tumors decrease in size or extent.

Using animals and tissue from humans, scientists observed that the RNA molecules of the SARS-CoV-2 virus, which is responsible for the disease, triggered the development of a special cell in the immune system that has anti-cancer properties.

Known as “inducible nonclassical monocytes” or “I-NCMs,” these special cells attack cancer cells and could be used to treat cancers that are resistant to current therapies, according to Northwestern Medicine Canning Thoracic Institute scientists.

From repairing deadly brain bleeds to tackling tumors with precise chemotherapy, micro/nano-robots (MNRs) are a promising, up-and-coming tool that have the power to substantially advance health care. However, this tool still has difficulty navigating within the human body—a limitation that has prevented it from entering clinical trials.

Mathematical models are crucial to the optimal design and navigation of MNRs, but the current models are inadequate. Now, new, promising research from the University of Saskatchewan (USask) may allow MNRs to overcome the limitations that previously prevented their widespread use.

USask College of Engineering professor Dr. Chris Zhang (Ph. D.) and two Ph.D. students (Lujia Ding, N.N Hu) along with two USask alumni (Dr. Bing Zhang (Ph. D.), Dr. R. Y. Yin (Ph. D.)) are the first team to develop a highly accurate mathematical model that optimizes the design of MNRs which improves their navigation, allowing them to travel efficiently through the bloodstream. Their work was recently published in Nature Communications.

Cognitive neuroscientists at Trinity College Dublin have published new research describing a brand new approach to making habit change achievable and lasting.

This innovative framework has the potential to significantly improve approaches to personal development, as well as the clinical treatment of compulsive disorders (for example obsessive compulsive disorder, addiction, and eating disorders).

The research was led by Dr. Eike Buabang, Postdoctoral Research Fellow in the lab of Professor Claire Gillan in the School of Psychology, has been published as a paper titled “Leveraging cognitive neuroscience for making and breaking real-world habits” in the journal Trends in Cognitive Sciences.

Researchers at University of Limerick in Ireland have developed a new method of growing organic crystals that can be used for energy-harvesting applications.

The energy that is being harvested as part of this research is being generated by squeezing amino acid molecules, the building blocks of proteins that exist in the human body.

Piezoelectricity, which translates from Greek to mean pressing electricity, usually found in ceramics or polymers, is also present in human biomolecules.

A new study demonstrates that even simple single-cell organisms, such as ciliates and amoebae, exhibit habituation, a basic form of learning previously thought to be exclusive to more complex beings.

This revelation not only changes our understanding of cellular capabilities but also opens up possibilities for applications in cancer immunology, suggesting that our immune cells might be reprogrammed to better recognize and attack cancer cells.

A dog learns to sit on command. A person tunes out the steady hum of a washing machine while engrossed in a book. The ability to learn and adapt is a cornerstone of evolution and survival.

The risk for thrombosis on equipment within coronary arteries during PCI – and the potential dangerous complications – has led to nearly 50 years of targeted research on the mechanisms of normal and pathologic thrombosis. This research has in turn led to the development of blood-thinning drug treatments to prevent thrombosis during and after PCI. However, the blood thinning (‘anti-thrombotic’) therapies can also lead to life-threatening excessive bleeding. Research to identify the optimal balance of anti-thrombotic drugs that minimises both pathologic thrombosis and excessive bleeding continues through today.

Dr Scott Denardo at Duke University Medical Center in the USA has modelled the behaviour of platelets inside blood vessels and near medical device surfaces. Some of his observations are just now entering the contemporary understanding of thrombosis. Denardo believes that applying these observations can refine existing anti-thrombotic therapies to improve their safety (less bleeding) while not compromising their effectiveness (preventing thrombosis on PCI equipment, including stents).