Mitochondria are the powerhouses of the cell. New research shows cancer cells can steal these energy generators from healthy cells to speed their growth.
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Which is why biophysicist Adam Lamson is collaborating with artist Laura Splan in a project the two of them call ‘Sticky Settings.’ It’s a kind of an inside joke about the nature of DNA strands, and the kinds of digital transformations that can be applied to data in animation software.
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The African turquoise killifish is an emerging vertebrate model organism with great potential for aging research due to its naturally short lifespan. Thus far, turquoise killifish aging omic studies using RNA-seq have examined a single organ, single sex and/or evaluated samples from non-reference strains. Here, we describe a resource dataset of ribosomal RNA depleted RNA-seq libraries generated from the brain, heart, muscle, and spleen from both sexes, as well as young and old animals, in the reference GRZ turquoise killifish strain. We provide basic quality control steps and demonstrate the utility of our dataset by performing differential gene expression and gene ontology analyses by age and sex. Importantly, we show that age has a greater impact than sex on transcriptional landscapes across probed tissues. Finally, we confirm transcription of transposable elements (TEs), which are highly abundant and increase in expression with age in brain tissue. This dataset will be a useful resource for exploring gene and TE expression as a function of both age and sex in a powerful naturally short-lived vertebrate model.
The authors have declared no competing interest.
From an emerging golden age in medicine to Microsoft’s quantum supercomputer, check out this week’s awesome tech stories from around the web.
Bacteria that contribute to gum disease may be a cause of the gynaecological condition endometriosis, which means it could be treated with antibiotics.
By Grace Wade
“This year, we’re introducing new features that use AI to help fans gain more insight and access commentary through our match highlights videos.”
Wimbledon, one of the most prestigious tennis tournaments in the world, is set to revolutionize its coverage this year by introducing artificial intelligence-powered commentary and analysis, according to a press release. The All England Club has partnered with tech giant IBM to offer fans a unique immersive experience with AI-generated audio commentary and captions in online highlights videos.
IBM, pioneers of AI-curated video highlights which earned the IBM Consulting team an Emmy Award, trained its bleeding-edge Watson AI platform in tennis… More.
Continue reading “Wimbledon to use IBM tech to power AI commentary for online highlights” »
Research from the Babraham Institute has developed a method to ‘time jump’ human skin cells by 30 years, turning back the ageing clock for cells without losing their specialised function. Work by researchers in the Institute’s Epigenetics research programme has been able to partly restore the function of older cells, as well as rejuvenating the molecular measures of biological age. The research is published today in the journal eLife and whilst at an early stage of exploration, it could revolutionise regenerative medicine.
What is regenerative medicine?
As we age, our cells’ ability to function declines and the genome accumulates marks of ageing. Regenerative biology aims to repair or replace cells including old ones. One of the most important tools in regenerative biology is our ability to create ‘induced’ stem cells. The process is a result of several steps, each erasing some of the marks that make cells specialised. In theory, these stem cells have the potential to become any cell type, but scientists aren’t yet able to reliably recreate the conditions to re-differentiate stem cells into all cell types.
Researchers have discovered a type of white blood cell in the lungs, called senescent macrophages, that promote tumor growth.
Some mutations were like a tax rebate and raised the propensity of TAR to adopt its biologically active structures, while other modifications raised the tax and decreased the odds that TAR would adopt a biologically active structure.
Hidden mechanism may lead to new drugs
“What we found was a hidden mechanism for controlling the activity of a molecule in a cell,” says Al-Hashimi. By altering the propensity of TAR to form biologically active states—by changing the tax rate—the researchers could fine-tune the molecule’s activity in cells.
The African turquoise killifish is an emerging vertebrate model organism with great potential for aging research due to its naturally short lifespan. Thus far, turquoise killifish aging omic studies using RNA-seq have examined a single organ, single sex and/or evaluated samples from non-reference strains. Here, we describe a resource dataset of ribosomal RNA depleted RNA-seq libraries generated from the brain, heart, muscle, and spleen from both sexes, as well as young and old animals, in the reference GRZ turquoise killifish strain. We provide basic quality control steps and demonstrate the utility of our dataset by performing differential gene expression and gene ontology analyses by age and sex. Importantly, we show that age has a greater impact than sex on transcriptional landscapes across probed tissues. Finally, we confirm transcription of transposable elements (TEs), which are highly abundant and increase in expression with age in brain tissue. This dataset will be a useful resource for exploring gene and TE expression as a function of both age and sex in a powerful naturally short-lived vertebrate model.
