Lifeboat Foundation

Year 2019 😗😁

Hepatology and drug development for liver diseases require in vitro liver models. Typical models include 2D planar primary hepatocytes, hepatocyte spheroids, hepatocyte organoids, and liver-on-a-chip. Liver-on-a-chip has emerged as the mainstream model for drug development because it recapitulates the liver microenvironment and has good assay robustness such as reproducibility. Liver-on-a-chip with human primary cells can potentially correlate clinical testing. Liver-on-a-chip can not only predict drug hepatotoxicity and drug metabolism, but also connect other artificial organs on the chip for a human-on-a-chip, which can reflect the overall effect of a drug. Engineering an effective liver-on-a-chip device requires knowledge of multiple disciplines including chemistry, fluidic mechanics, cell biology, electrics, and optics.

Year 2021

Brain organoids derived from human pluripotent stem cells can model human brain development and disease, though current culture systems fail to ensure reliable production of high-quality organoids. Here the authors combine human brain extracellular matrix and culture in a microfluidic device to promote structural and functional maturation of human brain organoids.

Elon Musk warns of a commercial real estate meltdown as valuations drop. New research shows the extent of that decline.

A U.K. teen with an aggressive form of leukemia is now cancer-free, thanks to a new gene-editing therapy.

The particular therapy used on the patient was only invented six years ago, and it’s now making doctors rethink the way doctors approach the disease.

Continue reading “Revolutionary gene-editing therapy treats girl’s ‘incurable’ cancer” »

This is an online article from the Christian Research Journal.

When you support the Journal, you join the team of to help provide the resources at equip.org that minister to people worldwide. These resources include our ever growing database of over 1,500 articles, as well as our free Postmodern Realities podcast.

The 2020 Nobel Prize for Chemistry was awarded to Dr. Jennifer Doudna and Dr. Emmanuelle Charpentier for their work on the gene editing technique known as CRISPR-Cas9. This gives us the ability to change the DNA of any living thing, from plants and animals to humans.

The applications are enormous, from improving farming to curing diseases. A decade or so from now, CRISPR will no doubt be taught in High Schools, and be a basic building block of medicine and agriculture. It is going to change everything.

Continue reading “Throw Forward Thursday: CRISPR” »

http://dx.doi.org/10.1016/j.neuron.2017.10.

Nishiyama et al. “Virus-Mediated Genome Editing via Homology-Directed Repair in Mitotic and Postmitotic Cells in Mammalian Brain.” Neuron (2017). doi:10.1016/j.neuron.2017.10.

Continue reading “Making CRISPR-Cas9 work in the brain” »

Researchers have for the first time characterised the molecular mechanism of the early stages of programmed cell death or apoptosis, a process which plays a crucial role in the prevention of cancer.

The study, published today (2 June) in Science Advances, was led by Dr Luke Clifton at the Science and Technology Facilities Council (STFC) ISIS Neutron and Muon Source (ISIS) in Oxfordshire. They worked alongside partners at the University of Umea and European Spallation Source in Sweden.

It is the most recent in a series of research collaborations by this team, investigating the cellular proteins responsible for apoptosis.

Yup that’s right a Tesla Affordable Home.

Known for turning a sofa in the Boca Chica SpaceX office into his bed, Elon Musk, The World’s Richest Man, took it to another level when he announced Tesla’s $10,000 sustainable unboxable moveable home. If you are remotely familiar with the Tesla CEO, you wouldn’t be surprised that he is building a sustainable home. So, how did Elon go from overhauling the tech space to completely disrupting the real estate industry?Well, it all started with this tweet from 2020. At the height of the pandemic, Elon Musk made this insane announcement.